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Towards open-ended evolution in self-replicating molecular systems

In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbound...

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Detalles Bibliográficos
Autores principales: Duim, Herman, Otto, Sijbren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496545/
https://www.ncbi.nlm.nih.gov/pubmed/28694865
http://dx.doi.org/10.3762/bjoc.13.118
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author Duim, Herman
Otto, Sijbren
author_facet Duim, Herman
Otto, Sijbren
author_sort Duim, Herman
collection PubMed
description In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.
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spelling pubmed-54965452017-07-10 Towards open-ended evolution in self-replicating molecular systems Duim, Herman Otto, Sijbren Beilstein J Org Chem Review In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory. Beilstein-Institut 2017-06-21 /pmc/articles/PMC5496545/ /pubmed/28694865 http://dx.doi.org/10.3762/bjoc.13.118 Text en Copyright © 2017, Duim and Otto https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Duim, Herman
Otto, Sijbren
Towards open-ended evolution in self-replicating molecular systems
title Towards open-ended evolution in self-replicating molecular systems
title_full Towards open-ended evolution in self-replicating molecular systems
title_fullStr Towards open-ended evolution in self-replicating molecular systems
title_full_unstemmed Towards open-ended evolution in self-replicating molecular systems
title_short Towards open-ended evolution in self-replicating molecular systems
title_sort towards open-ended evolution in self-replicating molecular systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496545/
https://www.ncbi.nlm.nih.gov/pubmed/28694865
http://dx.doi.org/10.3762/bjoc.13.118
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