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Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

Novel 13α-estrone derivatives were synthesized by Sonogashira coupling. Transformations of 2- or 4-iodo regioisomers of 13α-estrone and its 3-methyl ether were carried out under different conditions in a microwave reactor. The 2-iodo isomers were reacted with para-substituted phenylacetylenes using...

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Detalles Bibliográficos
Autores principales:	Bacsa, Ildikó, Jójárt, Rebeka, Wölfling, János, Schneider, Gyula, Herman, Bianka Edina, Szécsi, Mihály, Mernyák, Erzsébet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2017
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496578/ https://www.ncbi.nlm.nih.gov/pubmed/28694873 http://dx.doi.org/10.3762/bjoc.13.126

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