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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a multiomics approach in mammalian cells treated with four types of mitochondrial stressors, we identify activating transcription factor 4 (ATF4) as...

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Detalles Bibliográficos
Autores principales:	Quirós, Pedro M., Prado, Miguel A., Zamboni, Nicola, D’Amico, Davide, Williams, Robert W., Finley, Daniel, Gygi, Steven P., Auwerx, Johan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496626/ https://www.ncbi.nlm.nih.gov/pubmed/28566324 http://dx.doi.org/10.1083/jcb.201702058

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