mTORC in β cells: more Than Only Recognizing Comestibles

The pathways regulating pancreatic β cell survival in diabetes are poorly understood. Here, Chau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701085) demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP–Mlx complex to suppress TXNIP, thereby protecting...

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Detalles Bibliográficos
Autores principales: Maedler, Kathrin, Ardestani, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496628/
https://www.ncbi.nlm.nih.gov/pubmed/28606927
http://dx.doi.org/10.1083/jcb.201704179
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author Maedler, Kathrin
Ardestani, Amin
author_facet Maedler, Kathrin
Ardestani, Amin
author_sort Maedler, Kathrin
collection PubMed
description The pathways regulating pancreatic β cell survival in diabetes are poorly understood. Here, Chau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701085) demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP–Mlx complex to suppress TXNIP, thereby protecting pancreatic β cells in the diabetic setting by inhibiting oxidative stress and mitochondrial dysfunction.
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spelling pubmed-54966282018-01-03 mTORC in β cells: more Than Only Recognizing Comestibles Maedler, Kathrin Ardestani, Amin J Cell Biol Commentary The pathways regulating pancreatic β cell survival in diabetes are poorly understood. Here, Chau et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701085) demonstrate that mTOR regulates the apoptotic machinery through binding to the ChREBP–Mlx complex to suppress TXNIP, thereby protecting pancreatic β cells in the diabetic setting by inhibiting oxidative stress and mitochondrial dysfunction. The Rockefeller University Press 2017-07-03 /pmc/articles/PMC5496628/ /pubmed/28606927 http://dx.doi.org/10.1083/jcb.201704179 Text en © 2017 Maedler and Ardestani http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Maedler, Kathrin
Ardestani, Amin
mTORC in β cells: more Than Only Recognizing Comestibles
title mTORC in β cells: more Than Only Recognizing Comestibles
title_full mTORC in β cells: more Than Only Recognizing Comestibles
title_fullStr mTORC in β cells: more Than Only Recognizing Comestibles
title_full_unstemmed mTORC in β cells: more Than Only Recognizing Comestibles
title_short mTORC in β cells: more Than Only Recognizing Comestibles
title_sort mtorc in β cells: more than only recognizing comestibles
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496628/
https://www.ncbi.nlm.nih.gov/pubmed/28606927
http://dx.doi.org/10.1083/jcb.201704179
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