Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specif...

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Autor principal: Sørensen, Jakob B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496633/
https://www.ncbi.nlm.nih.gov/pubmed/28626002
http://dx.doi.org/10.1083/jcb.201706007
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author Sørensen, Jakob B.
author_facet Sørensen, Jakob B.
author_sort Sørensen, Jakob B.
collection PubMed
description The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I–associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.
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spelling pubmed-54966332018-01-03 Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3 Sørensen, Jakob B. J Cell Biol Commentary The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I–associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation. The Rockefeller University Press 2017-07-03 /pmc/articles/PMC5496633/ /pubmed/28626002 http://dx.doi.org/10.1083/jcb.201706007 Text en © 2017 Sørensen http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Sørensen, Jakob B.
Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title_full Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title_fullStr Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title_full_unstemmed Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title_short Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
title_sort ride the wave: retrograde trafficking becomes ca(2+) dependent with baiap3
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496633/
https://www.ncbi.nlm.nih.gov/pubmed/28626002
http://dx.doi.org/10.1083/jcb.201706007
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