KRS: A cut away from release in exosomes

Cancer cells often trigger an inflammatory process, which in some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium. Kim et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605118) now demonstrate that cleavage of the KRS by caspase-8 inside cells triggers its i...

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Detalles Bibliográficos
Autor principal: Rabouille, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496635/
https://www.ncbi.nlm.nih.gov/pubmed/28626001
http://dx.doi.org/10.1083/jcb.201706039
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author Rabouille, Catherine
author_facet Rabouille, Catherine
author_sort Rabouille, Catherine
collection PubMed
description Cancer cells often trigger an inflammatory process, which in some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium. Kim et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605118) now demonstrate that cleavage of the KRS by caspase-8 inside cells triggers its interaction with syntenin and its release in inflammatory exosomes.
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spelling pubmed-54966352018-01-03 KRS: A cut away from release in exosomes Rabouille, Catherine J Cell Biol Commentary Cancer cells often trigger an inflammatory process, which in some cases may be driven by the presence of lysyl-tRNA synthetase (KRS) in the medium. Kim et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201605118) now demonstrate that cleavage of the KRS by caspase-8 inside cells triggers its interaction with syntenin and its release in inflammatory exosomes. The Rockefeller University Press 2017-07-03 /pmc/articles/PMC5496635/ /pubmed/28626001 http://dx.doi.org/10.1083/jcb.201706039 Text en © 2017 Rabouille http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Rabouille, Catherine
KRS: A cut away from release in exosomes
title KRS: A cut away from release in exosomes
title_full KRS: A cut away from release in exosomes
title_fullStr KRS: A cut away from release in exosomes
title_full_unstemmed KRS: A cut away from release in exosomes
title_short KRS: A cut away from release in exosomes
title_sort krs: a cut away from release in exosomes
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496635/
https://www.ncbi.nlm.nih.gov/pubmed/28626001
http://dx.doi.org/10.1083/jcb.201706039
work_keys_str_mv AT rabouillecatherine krsacutawayfromreleaseinexosomes

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