RASSF4: Regulator of plasma membrane PI(4,5)P(2)

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane–cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS...

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Detalles Bibliográficos
Autor principal: Dickson, Eamonn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496636/
https://www.ncbi.nlm.nih.gov/pubmed/28634262
http://dx.doi.org/10.1083/jcb.201706042
Descripción
Sumario:Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane–cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RASSF4) positively influences PI(4,5)P(2) synthesis through ARF6-dependent regulation of PIP5K.

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