Polyglycerol-opioid conjugate produces analgesia devoid of side effects

Novel painkillers are urgently needed. The activation of opioid receptors in peripheral inflamed tissue can reduce pain without central adverse effects such as sedation, apnoea, or addiction. Here, we use an unprecedented strategy and report the synthesis and analgesic efficacy of the standard opioi...

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Detalles Bibliográficos
Autores principales: González-Rodríguez, Sara, Quadir, Mohiuddin A, Gupta, Shilpi, Walker, Karolina A, Zhang, Xuejiao, Spahn, Viola, Labuz, Dominika, Rodriguez-Gaztelumendi, Antonio, Schmelz, Martin, Joseph, Jan, Parr, Maria K, Machelska, Halina, Haag, Rainer, Stein, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496737/
https://www.ncbi.nlm.nih.gov/pubmed/28673386
http://dx.doi.org/10.7554/eLife.27081

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