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Extracellular matrix promotes clathrin-dependent endocytosis of prolactin and STAT5 activation in differentiating mammary epithelial cells

The hormone prolactin promotes lactational differentiation of mammary epithelial cells (MECs) via its cognate receptor and the downstream JAK2-STAT5a signalling pathway. In turn this regulates transcription of milk protein genes. Prolactin signalling depends on a cross-talk with basement membrane ex...

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Detalles Bibliográficos
Autores principales:	Bridgewater, Rebecca E., Streuli, Charles H., Caswell, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496899/ https://www.ncbi.nlm.nih.gov/pubmed/28676702 http://dx.doi.org/10.1038/s41598-017-04783-6

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