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Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein

Accumulating evidence from different lines of research suggests an involvement of the immune system in the pathophysiology of several psychiatric disorders. During recent years, a series of positron emission tomography (PET) studies have been published using radioligands for the translocator protein...

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Autores principales: van der Doef, Thalia F., Doorduin, Janine, van Berckel, Bart N. M., Cervenka, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496979/
https://www.ncbi.nlm.nih.gov/pubmed/28781965
http://dx.doi.org/10.1007/s40336-015-0140-0
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author van der Doef, Thalia F.
Doorduin, Janine
van Berckel, Bart N. M.
Cervenka, Simon
author_facet van der Doef, Thalia F.
Doorduin, Janine
van Berckel, Bart N. M.
Cervenka, Simon
author_sort van der Doef, Thalia F.
collection PubMed
description Accumulating evidence from different lines of research suggests an involvement of the immune system in the pathophysiology of several psychiatric disorders. During recent years, a series of positron emission tomography (PET) studies have been published using radioligands for the translocator protein (TSPO) to study microglia activation in schizophrenia, bipolar I disorder, major depression, autism spectrum disorder, and drug abuse. The results have been somewhat conflicting, which could be due to differences both in patient sample characteristics and in PET methods. In particular, further work is needed to address both methodological and biological sources of variability in TSPO levels, a process in which the use of animal models and small animal PET systems can be a valuable tool. Given this development, PET studies of immune activation have the potential to further increase our understanding of disease mechanisms in psychiatric disorders, which is a requisite in the search for new treatment approaches. Furthermore, molecular imaging could become an important clinical tool for identifying specific subgroups of patients or disease stages that would benefit from treatment targeting the immune system.
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spelling pubmed-54969792017-08-02 Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein van der Doef, Thalia F. Doorduin, Janine van Berckel, Bart N. M. Cervenka, Simon Clin Transl Imaging Review Article Accumulating evidence from different lines of research suggests an involvement of the immune system in the pathophysiology of several psychiatric disorders. During recent years, a series of positron emission tomography (PET) studies have been published using radioligands for the translocator protein (TSPO) to study microglia activation in schizophrenia, bipolar I disorder, major depression, autism spectrum disorder, and drug abuse. The results have been somewhat conflicting, which could be due to differences both in patient sample characteristics and in PET methods. In particular, further work is needed to address both methodological and biological sources of variability in TSPO levels, a process in which the use of animal models and small animal PET systems can be a valuable tool. Given this development, PET studies of immune activation have the potential to further increase our understanding of disease mechanisms in psychiatric disorders, which is a requisite in the search for new treatment approaches. Furthermore, molecular imaging could become an important clinical tool for identifying specific subgroups of patients or disease stages that would benefit from treatment targeting the immune system. Springer Milan 2015-09-10 2015 /pmc/articles/PMC5496979/ /pubmed/28781965 http://dx.doi.org/10.1007/s40336-015-0140-0 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
spellingShingle Review Article
van der Doef, Thalia F.
Doorduin, Janine
van Berckel, Bart N. M.
Cervenka, Simon
Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title_full Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title_fullStr Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title_full_unstemmed Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title_short Assessing brain immune activation in psychiatric disorders: clinical and preclinical PET imaging studies of the 18-kDa translocator protein
title_sort assessing brain immune activation in psychiatric disorders: clinical and preclinical pet imaging studies of the 18-kda translocator protein
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496979/
https://www.ncbi.nlm.nih.gov/pubmed/28781965
http://dx.doi.org/10.1007/s40336-015-0140-0
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