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Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes

It has been reported that there is an intimate relationship between diabetes and bone metabolism including undercarboxylated osteocalcin (ucOC). In contrast, data on the relationship between ucOC and glucose metabolism are limited in type 2 diabetes. We recruited 50 Japanese patients with type 2 dia...

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Autores principales: Takashi, Yuichi, Koga, Minae, Matsuzawa, Yoko, Saito, Jun, Omura, Masao, Nishikawa, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497042/
https://www.ncbi.nlm.nih.gov/pubmed/27889949
http://dx.doi.org/10.1111/jdi.12601
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author Takashi, Yuichi
Koga, Minae
Matsuzawa, Yoko
Saito, Jun
Omura, Masao
Nishikawa, Tetsuo
author_facet Takashi, Yuichi
Koga, Minae
Matsuzawa, Yoko
Saito, Jun
Omura, Masao
Nishikawa, Tetsuo
author_sort Takashi, Yuichi
collection PubMed
description It has been reported that there is an intimate relationship between diabetes and bone metabolism including undercarboxylated osteocalcin (ucOC). In contrast, data on the relationship between ucOC and glucose metabolism are limited in type 2 diabetes. We recruited 50 Japanese patients with type 2 diabetes, and examined the association with ucOC on the insulin secretion, evaluated by both glucagon loading test and meal tolerance test. UcOC was shown to correlate positively with the change in C‐peptide response in the glucagon loading test and C‐peptide response after eating a meal (P = 0.025, P = 0.047). Therefore, ucOC reflects the reserve capacity of β‐cell function, such as the bolus insulin secretion ability in patients with type 2 diabetes.
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spelling pubmed-54970422017-07-14 Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes Takashi, Yuichi Koga, Minae Matsuzawa, Yoko Saito, Jun Omura, Masao Nishikawa, Tetsuo J Diabetes Investig Articles It has been reported that there is an intimate relationship between diabetes and bone metabolism including undercarboxylated osteocalcin (ucOC). In contrast, data on the relationship between ucOC and glucose metabolism are limited in type 2 diabetes. We recruited 50 Japanese patients with type 2 diabetes, and examined the association with ucOC on the insulin secretion, evaluated by both glucagon loading test and meal tolerance test. UcOC was shown to correlate positively with the change in C‐peptide response in the glucagon loading test and C‐peptide response after eating a meal (P = 0.025, P = 0.047). Therefore, ucOC reflects the reserve capacity of β‐cell function, such as the bolus insulin secretion ability in patients with type 2 diabetes. John Wiley and Sons Inc. 2017-01-25 2017-07 /pmc/articles/PMC5497042/ /pubmed/27889949 http://dx.doi.org/10.1111/jdi.12601 Text en © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Takashi, Yuichi
Koga, Minae
Matsuzawa, Yoko
Saito, Jun
Omura, Masao
Nishikawa, Tetsuo
Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title_full Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title_fullStr Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title_full_unstemmed Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title_short Undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
title_sort undercarboxylated osteocalcin can predict insulin secretion ability in type 2 diabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497042/
https://www.ncbi.nlm.nih.gov/pubmed/27889949
http://dx.doi.org/10.1111/jdi.12601
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