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Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals

AIMS/INTRODUCTION: Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes...

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Autores principales: Akter, Shamima, Nanri, Akiko, Kuwahara, Keisuke, Matsushita, Yumi, Nakagawa, Tohru, Konishi, Maki, Honda, Toru, Yamamoto, Shuichiro, Hayashi, Takeshi, Noda, Mitsuhiko, Mizoue, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497053/
https://www.ncbi.nlm.nih.gov/pubmed/28060459
http://dx.doi.org/10.1111/jdi.12617
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author Akter, Shamima
Nanri, Akiko
Kuwahara, Keisuke
Matsushita, Yumi
Nakagawa, Tohru
Konishi, Maki
Honda, Toru
Yamamoto, Shuichiro
Hayashi, Takeshi
Noda, Mitsuhiko
Mizoue, Tetsuya
author_facet Akter, Shamima
Nanri, Akiko
Kuwahara, Keisuke
Matsushita, Yumi
Nakagawa, Tohru
Konishi, Maki
Honda, Toru
Yamamoto, Shuichiro
Hayashi, Takeshi
Noda, Mitsuhiko
Mizoue, Tetsuya
author_sort Akter, Shamima
collection PubMed
description AIMS/INTRODUCTION: Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals. MATERIALS AND METHODS: The participants were 4,754 employees who attended a comprehensive health check‐up in 2008–2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self‐report. Two controls matched to each case on sex, age and date of check‐up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional hazards regression was used to estimate the hazard ratio while adjusting for a series of potential confounders or mediators. RESULTS: Elevated serum ferritin levels were associated with a significantly increased risk of type 2 diabetes, with the hazard ratio adjusted for known risk factors in the highest vs lowest quartile of 1.42 (95% confidence interval: 1.03–1.96). This association was unchanged after adjustment for C‐reactive protein and adiponectin, but attenuated after adjustment for liver enzyme and insulin resistance (hazard ratio 1.04). The ferritin–diabetes association was confined to non‐obese participants. CONCLUSIONS: These results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance.
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spelling pubmed-54970532017-07-14 Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals Akter, Shamima Nanri, Akiko Kuwahara, Keisuke Matsushita, Yumi Nakagawa, Tohru Konishi, Maki Honda, Toru Yamamoto, Shuichiro Hayashi, Takeshi Noda, Mitsuhiko Mizoue, Tetsuya J Diabetes Investig Articles AIMS/INTRODUCTION: Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals. MATERIALS AND METHODS: The participants were 4,754 employees who attended a comprehensive health check‐up in 2008–2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self‐report. Two controls matched to each case on sex, age and date of check‐up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional hazards regression was used to estimate the hazard ratio while adjusting for a series of potential confounders or mediators. RESULTS: Elevated serum ferritin levels were associated with a significantly increased risk of type 2 diabetes, with the hazard ratio adjusted for known risk factors in the highest vs lowest quartile of 1.42 (95% confidence interval: 1.03–1.96). This association was unchanged after adjustment for C‐reactive protein and adiponectin, but attenuated after adjustment for liver enzyme and insulin resistance (hazard ratio 1.04). The ferritin–diabetes association was confined to non‐obese participants. CONCLUSIONS: These results suggest that elevated iron storage is associated with increased risk of type 2 diabetes in normal weight individuals, and that this association is partly mediated through liver dysfunction and resulting insulin resistance. John Wiley and Sons Inc. 2017-03-06 2017-07 /pmc/articles/PMC5497053/ /pubmed/28060459 http://dx.doi.org/10.1111/jdi.12617 Text en © 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Akter, Shamima
Nanri, Akiko
Kuwahara, Keisuke
Matsushita, Yumi
Nakagawa, Tohru
Konishi, Maki
Honda, Toru
Yamamoto, Shuichiro
Hayashi, Takeshi
Noda, Mitsuhiko
Mizoue, Tetsuya
Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title_full Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title_fullStr Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title_full_unstemmed Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title_short Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals
title_sort circulating ferritin concentrations and risk of type 2 diabetes in japanese individuals
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497053/
https://www.ncbi.nlm.nih.gov/pubmed/28060459
http://dx.doi.org/10.1111/jdi.12617
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