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Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs

PURPOSE: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. METHODS: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (...

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Autores principales: Li, Xing, Liao, Limin, Chen, Guoqing, Wang, Zhaoxia, Deng, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Continence Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497198/
https://www.ncbi.nlm.nih.gov/pubmed/28673064
http://dx.doi.org/10.5213/inj.1732754.377
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author Li, Xing
Liao, Limin
Chen, Guoqing
Wang, Zhaoxia
Deng, Han
author_facet Li, Xing
Liao, Limin
Chen, Guoqing
Wang, Zhaoxia
Deng, Han
author_sort Li, Xing
collection PubMed
description PURPOSE: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. METHODS: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 µsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different frequencies on the micturition reflex. RESULTS: AA-induced bladder overactivity significantly reduced the bladder capacity (BC) to 34.4%±4.7% of the NS control level (354.4±35.9 mL) (P<0.05). During AA infusion, SNM at 5 Hz did not significantly change the BC (48.1%±6.9% of the NS control level) (P>0.05), but SNM at 15, 30, and 50 Hz significantly increased the BC to 54.5%±7.1%, 55.2%±6.5%, and 57.2%±6.1% of the NS control level (P<0.05), respectively. No significant differences were found among the results obtained using frequencies of 15, 30, and 50 Hz (P>0.05). CONCLUSIONS: This study demonstrated that 15 Hz was an appropriate frequency for SNM and that frequencies higher than 15 Hz did not lead to better surgical outcomes.
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spelling pubmed-54971982017-07-05 Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs Li, Xing Liao, Limin Chen, Guoqing Wang, Zhaoxia Deng, Han Int Neurourol J Original Article PURPOSE: We investigated the effects of different stimulation frequencies on the inhibition of bladder overactivity by sacral neuromodulation (SNM) in pigs. METHODS: Implant-driven stimulators were used to stimulate the S3 spinal nerve in 13 pigs. Cystometry was performed by infusing normal saline (NS) or acetic acid (AA). SNM (pulse width, 210 µsec) at frequencies ranging from 5 to 50 Hz was conducted at the intensity threshold at which observable perianal and/or tail movement was induced. Multiple cystometrograms were performed to determine the effects of different frequencies on the micturition reflex. RESULTS: AA-induced bladder overactivity significantly reduced the bladder capacity (BC) to 34.4%±4.7% of the NS control level (354.4±35.9 mL) (P<0.05). During AA infusion, SNM at 5 Hz did not significantly change the BC (48.1%±6.9% of the NS control level) (P>0.05), but SNM at 15, 30, and 50 Hz significantly increased the BC to 54.5%±7.1%, 55.2%±6.5%, and 57.2%±6.1% of the NS control level (P<0.05), respectively. No significant differences were found among the results obtained using frequencies of 15, 30, and 50 Hz (P>0.05). CONCLUSIONS: This study demonstrated that 15 Hz was an appropriate frequency for SNM and that frequencies higher than 15 Hz did not lead to better surgical outcomes. Korean Continence Society 2017-06 2017-06-21 /pmc/articles/PMC5497198/ /pubmed/28673064 http://dx.doi.org/10.5213/inj.1732754.377 Text en Copyright © 2017 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Li, Xing
Liao, Limin
Chen, Guoqing
Wang, Zhaoxia
Deng, Han
Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title_full Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title_fullStr Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title_full_unstemmed Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title_short Effects of Acute Sacral Neuromodulation at Different Frequencies on Bladder Overactivity in Pigs
title_sort effects of acute sacral neuromodulation at different frequencies on bladder overactivity in pigs
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497198/
https://www.ncbi.nlm.nih.gov/pubmed/28673064
http://dx.doi.org/10.5213/inj.1732754.377
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