Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

OBJECTIVE: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). METHODS: We collected GPS and clinicopa...

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Detalles Bibliográficos
Autores principales: Chang, Pei-Hung, Wang, Cheng-Hsu, Chen, Eric Yen-Chao, Yang, Shih-Wei, Chou, Wen-Chi, Hsieh, Jason Chia-Hsun, Kuan, Feng-Che, Yeh, Kun-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497203/
https://www.ncbi.nlm.nih.gov/pubmed/28729767
http://dx.doi.org/10.21147/j.issn.1000-9604.2017.03.02
Descripción
Sumario:OBJECTIVE: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). METHODS: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. RESULTS: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. CONCLUSIONS: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

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