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The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients
BACKGROUND: In chronic heart failure (CHF) patients there is a wide variability in the minimal effective diuretic dose. The aim of this study is to evaluate whether renal resistance index (RRI) is associated to baseline diuretic dose and the changes at one year. METHODS AND RESULTS: 250 outpatients...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497238/ https://www.ncbi.nlm.nih.gov/pubmed/28785659 http://dx.doi.org/10.1016/j.ijcha.2015.03.004 |
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author | Iacoviello, Massimo Doronzo, Annalisa Paradies, Valeria Antoncecchi, Valeria Monitillo, Francesco Citarelli, Gaetano Leone, Marta Puzzovivo, Agata Gesualdo, Loreto Ciccone, Marco Matteo |
author_facet | Iacoviello, Massimo Doronzo, Annalisa Paradies, Valeria Antoncecchi, Valeria Monitillo, Francesco Citarelli, Gaetano Leone, Marta Puzzovivo, Agata Gesualdo, Loreto Ciccone, Marco Matteo |
author_sort | Iacoviello, Massimo |
collection | PubMed |
description | BACKGROUND: In chronic heart failure (CHF) patients there is a wide variability in the minimal effective diuretic dose. The aim of this study is to evaluate whether renal resistance index (RRI) is associated to baseline diuretic dose and the changes at one year. METHODS AND RESULTS: 250 outpatients in a stable condition and in conventional therapy were enrolled. Baseline RRI was calculated by renal arterial Doppler. The total daily dose of loop diuretics was assessed at baseline and after one year. High diuretic dose (HDD) was defined as a daily furosemide equivalent dose > 100 mg. RRI was independently associated with baseline HDD at univariate (OR 1.39; 95% CI: 1.233–1.58; p < 0.001) and multivariate analysis (OR 1.27; 95% CI: 1.09–1.49; p: 0.002) after correction for other univariate predictors (age, NYHA class, left ventricular ejection fraction, tricuspid annulus peak of systolic excursion, NT-proBNP, glomerular filtration rate by EPI formula and central venous pressure). Moreover, baseline RRI was independently associated to one year stable increase in loop diuretic dose at univariate and multivariate regression analyses. CONCLUSIONS: RRI is independently associated with high dose loop diuretics and their increase during a mid-term follow-up thus suggesting its usefulness in detecting an altered diuretic response in CHF outpatients. |
format | Online Article Text |
id | pubmed-5497238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54972382017-08-07 The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients Iacoviello, Massimo Doronzo, Annalisa Paradies, Valeria Antoncecchi, Valeria Monitillo, Francesco Citarelli, Gaetano Leone, Marta Puzzovivo, Agata Gesualdo, Loreto Ciccone, Marco Matteo Int J Cardiol Heart Vasc Article BACKGROUND: In chronic heart failure (CHF) patients there is a wide variability in the minimal effective diuretic dose. The aim of this study is to evaluate whether renal resistance index (RRI) is associated to baseline diuretic dose and the changes at one year. METHODS AND RESULTS: 250 outpatients in a stable condition and in conventional therapy were enrolled. Baseline RRI was calculated by renal arterial Doppler. The total daily dose of loop diuretics was assessed at baseline and after one year. High diuretic dose (HDD) was defined as a daily furosemide equivalent dose > 100 mg. RRI was independently associated with baseline HDD at univariate (OR 1.39; 95% CI: 1.233–1.58; p < 0.001) and multivariate analysis (OR 1.27; 95% CI: 1.09–1.49; p: 0.002) after correction for other univariate predictors (age, NYHA class, left ventricular ejection fraction, tricuspid annulus peak of systolic excursion, NT-proBNP, glomerular filtration rate by EPI formula and central venous pressure). Moreover, baseline RRI was independently associated to one year stable increase in loop diuretic dose at univariate and multivariate regression analyses. CONCLUSIONS: RRI is independently associated with high dose loop diuretics and their increase during a mid-term follow-up thus suggesting its usefulness in detecting an altered diuretic response in CHF outpatients. Elsevier 2015-03-25 /pmc/articles/PMC5497238/ /pubmed/28785659 http://dx.doi.org/10.1016/j.ijcha.2015.03.004 Text en © 2015 Published by Elsevier Ireland Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Iacoviello, Massimo Doronzo, Annalisa Paradies, Valeria Antoncecchi, Valeria Monitillo, Francesco Citarelli, Gaetano Leone, Marta Puzzovivo, Agata Gesualdo, Loreto Ciccone, Marco Matteo The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title | The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title_full | The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title_fullStr | The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title_full_unstemmed | The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title_short | The independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
title_sort | independent association between altered renal arterial resistance and loop diuretic dose in chronic heart failure outpatients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497238/ https://www.ncbi.nlm.nih.gov/pubmed/28785659 http://dx.doi.org/10.1016/j.ijcha.2015.03.004 |
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