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A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies

Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer patients. For the upper extremities, it is most commonly associated with prior oncologic th...

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Autores principales: Garza, Ramon, Skoracki, Roman, Hock, Karen, Povoski, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497342/
https://www.ncbi.nlm.nih.gov/pubmed/28679373
http://dx.doi.org/10.1186/s12885-017-3444-9
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author Garza, Ramon
Skoracki, Roman
Hock, Karen
Povoski, Stephen P.
author_facet Garza, Ramon
Skoracki, Roman
Hock, Karen
Povoski, Stephen P.
author_sort Garza, Ramon
collection PubMed
description Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer patients. For the upper extremities, it is most commonly associated with prior oncologic therapies for breast cancer, while for the lower extremities, it is most commonly associated with oncologic therapies for gynecologic cancers, urologic cancers, melanoma, and lymphoma. Both non-surgical and surgical management strategies have been developed and utilized, with the primary goal of all management strategies being volume reduction of the affected extremity, improvement in patient symptomology, and the reduction/elimination of resultant extremity-related morbidities, including recurrent infections. Surgical management strategies include: (i) ablative surgical methods (i.e., Charles procedure, suction-assisted lipectomy/liposuction) and (ii) physiologic surgical methods (i.e., lymphaticolymphatic bypass, lymphaticovenular anastomosis, vascularized lymph node transfer, vascularized omental flap transfer). While these surgical management strategies can result in dramatic improvement in extremity-related symptomology and improve quality of life for these cancer patients, many formidable challenges remain for successful management of secondary lymphedema. It is hopeful that ongoing clinical research efforts will ultimately lead to more complete and sustainable treatment strategies and perhaps a cure for secondary lymphedema and its devastating resultant morbidities.
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spelling pubmed-54973422017-07-07 A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies Garza, Ramon Skoracki, Roman Hock, Karen Povoski, Stephen P. BMC Cancer Review Secondary lymphedema of the upper and lower extremities related to prior oncologic therapies, including cancer surgeries, radiation therapy, and chemotherapy, is a major cause of long-term morbidity in cancer patients. For the upper extremities, it is most commonly associated with prior oncologic therapies for breast cancer, while for the lower extremities, it is most commonly associated with oncologic therapies for gynecologic cancers, urologic cancers, melanoma, and lymphoma. Both non-surgical and surgical management strategies have been developed and utilized, with the primary goal of all management strategies being volume reduction of the affected extremity, improvement in patient symptomology, and the reduction/elimination of resultant extremity-related morbidities, including recurrent infections. Surgical management strategies include: (i) ablative surgical methods (i.e., Charles procedure, suction-assisted lipectomy/liposuction) and (ii) physiologic surgical methods (i.e., lymphaticolymphatic bypass, lymphaticovenular anastomosis, vascularized lymph node transfer, vascularized omental flap transfer). While these surgical management strategies can result in dramatic improvement in extremity-related symptomology and improve quality of life for these cancer patients, many formidable challenges remain for successful management of secondary lymphedema. It is hopeful that ongoing clinical research efforts will ultimately lead to more complete and sustainable treatment strategies and perhaps a cure for secondary lymphedema and its devastating resultant morbidities. BioMed Central 2017-07-05 /pmc/articles/PMC5497342/ /pubmed/28679373 http://dx.doi.org/10.1186/s12885-017-3444-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Garza, Ramon
Skoracki, Roman
Hock, Karen
Povoski, Stephen P.
A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title_full A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title_fullStr A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title_full_unstemmed A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title_short A comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
title_sort comprehensive overview on the surgical management of secondary lymphedema of the upper and lower extremities related to prior oncologic therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497342/
https://www.ncbi.nlm.nih.gov/pubmed/28679373
http://dx.doi.org/10.1186/s12885-017-3444-9
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