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Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)

BACKGROUND: French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presente...

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Autores principales: Mayousse, Vincent, Desquilbet, Loïc, Jeandel, Aurélien, Blot, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497356/
https://www.ncbi.nlm.nih.gov/pubmed/28676057
http://dx.doi.org/10.1186/s12917-017-1132-2
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author Mayousse, Vincent
Desquilbet, Loïc
Jeandel, Aurélien
Blot, Stéphane
author_facet Mayousse, Vincent
Desquilbet, Loïc
Jeandel, Aurélien
Blot, Stéphane
author_sort Mayousse, Vincent
collection PubMed
description BACKGROUND: French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presented with neurological signs between 2002 and 2016, and for which a definitive diagnosis was established. A secondary objective was to identify epidemiological characteristics regarding specific diseases in this singular breed. RESULTS: During the study period, 533 FBs were presented for neurological signs, representing 18.7% of all admitted FBs (N = 2846). In total, 343 FBs with definitive diagnosis were included in this descriptive epidemiological study. Hansen type I intervertebral disk herniation (IVDH) was by far the most common neurological disorder (45.5% of all cases). The IVDH location was cervical in 39.8%, and thoracolumbar in 60.2% of cases. The median ages for cervical and thoracolumbar IVDH were 4.2 and 4 years, respectively. C3-C4 was the most commonly affected disk (57.8% of cervical IDVH) all locations combined. Spinal arachnoid diverticulum (SAD) was detected in 25 FBs, representing the second most common myelopathy (11.3%). A concurrent spinal abnormality was identified in 64.0% of SAD cases. Brain tumours represented 36.8% of encephalopathies, with glioma (confirmed or suspected) being the most common. Meningoencephalitis of unknown origin (MUO) represented 25.0% of brain disorders, females less than 5.5 years being more likely to be affected. Aside from central nervous system conditions, otitis interna associated with peripheral vestibular signs and bilateral congenital deafness (associated with white coat) were also common. CONCLUSIONS: The findings of this study suggest that FB seems to be prone to several neurological diseases. IVDH is clearly predominant in FB and cervical location seems more represented than in other breeds. FBs affected by IVDH tend to be younger than previously described, either for both cervical and thoracolumbar locations. Thoracic SAD was the second most common myelopathy, with a concurrent spinal anomaly identified in two thirds of the cases. MUO was more likely to affect young to middle-aged females. These findings could be of interest for owners, breeders, practicing veterinarians and insurance companies.
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spelling pubmed-54973562017-07-07 Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016) Mayousse, Vincent Desquilbet, Loïc Jeandel, Aurélien Blot, Stéphane BMC Vet Res Research Article BACKGROUND: French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was to report the prevalences of neurological diseases in a large population of FB, presented with neurological signs between 2002 and 2016, and for which a definitive diagnosis was established. A secondary objective was to identify epidemiological characteristics regarding specific diseases in this singular breed. RESULTS: During the study period, 533 FBs were presented for neurological signs, representing 18.7% of all admitted FBs (N = 2846). In total, 343 FBs with definitive diagnosis were included in this descriptive epidemiological study. Hansen type I intervertebral disk herniation (IVDH) was by far the most common neurological disorder (45.5% of all cases). The IVDH location was cervical in 39.8%, and thoracolumbar in 60.2% of cases. The median ages for cervical and thoracolumbar IVDH were 4.2 and 4 years, respectively. C3-C4 was the most commonly affected disk (57.8% of cervical IDVH) all locations combined. Spinal arachnoid diverticulum (SAD) was detected in 25 FBs, representing the second most common myelopathy (11.3%). A concurrent spinal abnormality was identified in 64.0% of SAD cases. Brain tumours represented 36.8% of encephalopathies, with glioma (confirmed or suspected) being the most common. Meningoencephalitis of unknown origin (MUO) represented 25.0% of brain disorders, females less than 5.5 years being more likely to be affected. Aside from central nervous system conditions, otitis interna associated with peripheral vestibular signs and bilateral congenital deafness (associated with white coat) were also common. CONCLUSIONS: The findings of this study suggest that FB seems to be prone to several neurological diseases. IVDH is clearly predominant in FB and cervical location seems more represented than in other breeds. FBs affected by IVDH tend to be younger than previously described, either for both cervical and thoracolumbar locations. Thoracic SAD was the second most common myelopathy, with a concurrent spinal anomaly identified in two thirds of the cases. MUO was more likely to affect young to middle-aged females. These findings could be of interest for owners, breeders, practicing veterinarians and insurance companies. BioMed Central 2017-07-05 /pmc/articles/PMC5497356/ /pubmed/28676057 http://dx.doi.org/10.1186/s12917-017-1132-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Mayousse, Vincent
Desquilbet, Loïc
Jeandel, Aurélien
Blot, Stéphane
Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title_full Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title_fullStr Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title_full_unstemmed Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title_short Prevalence of neurological disorders in French bulldog: a retrospective study of 343 cases (2002–2016)
title_sort prevalence of neurological disorders in french bulldog: a retrospective study of 343 cases (2002–2016)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497356/
https://www.ncbi.nlm.nih.gov/pubmed/28676057
http://dx.doi.org/10.1186/s12917-017-1132-2
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