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Autoimmune reactions in the course of the hepatitis C virus (HCV) infection

The immune response to the presence of the virus, both specific and non-specific, plays a decisive role in the natural history of the infection, and influences the intensity of lesions in the liver. Despite the great progress which we were able to observe over the last several years, many issues sti...

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Autores principales: Tomasiewicz, Krzysztof, Pokora-Pachowicz, Agnieszka, Kiciak, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497407/
https://www.ncbi.nlm.nih.gov/pubmed/28856254
http://dx.doi.org/10.5114/ceh.2015.51804
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author Tomasiewicz, Krzysztof
Pokora-Pachowicz, Agnieszka
Kiciak, Sławomir
author_facet Tomasiewicz, Krzysztof
Pokora-Pachowicz, Agnieszka
Kiciak, Sławomir
author_sort Tomasiewicz, Krzysztof
collection PubMed
description The immune response to the presence of the virus, both specific and non-specific, plays a decisive role in the natural history of the infection, and influences the intensity of lesions in the liver. Despite the great progress which we were able to observe over the last several years, many issues still require clarification. The problem of autoimmune reactions during hepatitis C virus (HCV) infection includes at least two issues. First, the risk of exacerbating reactions against the organism’s own tissues that existed before the treatment. There is also an increased risk of the development of de novo autoimmune reactions, triggered mostly by interferon α. Hepatitis C virus infection predisposes to the development of diseases characterised as being certainly or probably immune-mediated. Currently the situation has changed due to introducing non-interferon therapies for HCV treatment, which eliminate the risk associated with immunotherapy in patients with autoimmune diseases, yet the therapies are not widely available.
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spelling pubmed-54974072017-08-30 Autoimmune reactions in the course of the hepatitis C virus (HCV) infection Tomasiewicz, Krzysztof Pokora-Pachowicz, Agnieszka Kiciak, Sławomir Clin Exp Hepatol Review Article The immune response to the presence of the virus, both specific and non-specific, plays a decisive role in the natural history of the infection, and influences the intensity of lesions in the liver. Despite the great progress which we were able to observe over the last several years, many issues still require clarification. The problem of autoimmune reactions during hepatitis C virus (HCV) infection includes at least two issues. First, the risk of exacerbating reactions against the organism’s own tissues that existed before the treatment. There is also an increased risk of the development of de novo autoimmune reactions, triggered mostly by interferon α. Hepatitis C virus infection predisposes to the development of diseases characterised as being certainly or probably immune-mediated. Currently the situation has changed due to introducing non-interferon therapies for HCV treatment, which eliminate the risk associated with immunotherapy in patients with autoimmune diseases, yet the therapies are not widely available. Termedia Publishing House 2015-06-02 2015-06 /pmc/articles/PMC5497407/ /pubmed/28856254 http://dx.doi.org/10.5114/ceh.2015.51804 Text en Copyright: © 2015 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Article
Tomasiewicz, Krzysztof
Pokora-Pachowicz, Agnieszka
Kiciak, Sławomir
Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title_full Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title_fullStr Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title_full_unstemmed Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title_short Autoimmune reactions in the course of the hepatitis C virus (HCV) infection
title_sort autoimmune reactions in the course of the hepatitis c virus (hcv) infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497407/
https://www.ncbi.nlm.nih.gov/pubmed/28856254
http://dx.doi.org/10.5114/ceh.2015.51804
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