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Primary intimal sarcoma of the left atrium presenting with constitutional symptoms

Intimal (spindle-cell) sarcomas are exceptionally rare and are highly aggressive cardiac tumors. The authors describe a case of a 43-year-old female, presenting with a 3-month history of constitutional symptoms with fever, night sweats, anorexia and weight loss, associated with productive cough and...

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Autores principales: Marques Mendes, Edite, Ferreira, António, Felgueiras, Paula, Silva, Augusta, Ribeiro, Carlos, Guerra, Diana, de Melo, Daniel Pereira, Manuel Lopes, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497514/
https://www.ncbi.nlm.nih.gov/pubmed/28694971
http://dx.doi.org/10.1093/omcr/omx031
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author Marques Mendes, Edite
Ferreira, António
Felgueiras, Paula
Silva, Augusta
Ribeiro, Carlos
Guerra, Diana
de Melo, Daniel Pereira
Manuel Lopes, José
author_facet Marques Mendes, Edite
Ferreira, António
Felgueiras, Paula
Silva, Augusta
Ribeiro, Carlos
Guerra, Diana
de Melo, Daniel Pereira
Manuel Lopes, José
author_sort Marques Mendes, Edite
collection PubMed
description Intimal (spindle-cell) sarcomas are exceptionally rare and are highly aggressive cardiac tumors. The authors describe a case of a 43-year-old female, presenting with a 3-month history of constitutional symptoms with fever, night sweats, anorexia and weight loss, associated with productive cough and pleural effusion that was admitted with clinical suspicion of pulmonary tuberculosis. The patient developed sudden acute heart failure symptoms during hospitalization, leading to mechanical ventilation. Computed tomography scan with contrast showed a cardiac tumor filling the left atrium causing compression of pulmonary veins. Surgical resection was performed and histologic examination revealed an intimal sarcoma. Although commenced on adjuvant chemotherapy, local tumor recurrence occurred with pericardium invasion. The patient died within 4 months of initial diagnosis. This report aims to describe an unusual presentation of this rare disease entity, and to discuss its highly aggressive clinical course.
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spelling pubmed-54975142017-07-10 Primary intimal sarcoma of the left atrium presenting with constitutional symptoms Marques Mendes, Edite Ferreira, António Felgueiras, Paula Silva, Augusta Ribeiro, Carlos Guerra, Diana de Melo, Daniel Pereira Manuel Lopes, José Oxf Med Case Reports Case Report Intimal (spindle-cell) sarcomas are exceptionally rare and are highly aggressive cardiac tumors. The authors describe a case of a 43-year-old female, presenting with a 3-month history of constitutional symptoms with fever, night sweats, anorexia and weight loss, associated with productive cough and pleural effusion that was admitted with clinical suspicion of pulmonary tuberculosis. The patient developed sudden acute heart failure symptoms during hospitalization, leading to mechanical ventilation. Computed tomography scan with contrast showed a cardiac tumor filling the left atrium causing compression of pulmonary veins. Surgical resection was performed and histologic examination revealed an intimal sarcoma. Although commenced on adjuvant chemotherapy, local tumor recurrence occurred with pericardium invasion. The patient died within 4 months of initial diagnosis. This report aims to describe an unusual presentation of this rare disease entity, and to discuss its highly aggressive clinical course. Oxford University Press 2017-07-05 /pmc/articles/PMC5497514/ /pubmed/28694971 http://dx.doi.org/10.1093/omcr/omx031 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Marques Mendes, Edite
Ferreira, António
Felgueiras, Paula
Silva, Augusta
Ribeiro, Carlos
Guerra, Diana
de Melo, Daniel Pereira
Manuel Lopes, José
Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title_full Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title_fullStr Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title_full_unstemmed Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title_short Primary intimal sarcoma of the left atrium presenting with constitutional symptoms
title_sort primary intimal sarcoma of the left atrium presenting with constitutional symptoms
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497514/
https://www.ncbi.nlm.nih.gov/pubmed/28694971
http://dx.doi.org/10.1093/omcr/omx031
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