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Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children

BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS...

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Autores principales: Afrifa, Justice, Gyedu, Desmond, Ofori Gyamerah, Eric, Essien-Baidoo, Samuel, Mensah-Essilfie, Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497644/
https://www.ncbi.nlm.nih.gov/pubmed/28713432
http://dx.doi.org/10.1155/2017/4248325
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author Afrifa, Justice
Gyedu, Desmond
Ofori Gyamerah, Eric
Essien-Baidoo, Samuel
Mensah-Essilfie, Isaac
author_facet Afrifa, Justice
Gyedu, Desmond
Ofori Gyamerah, Eric
Essien-Baidoo, Samuel
Mensah-Essilfie, Isaac
author_sort Afrifa, Justice
collection PubMed
description BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS AND METHODS: A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. RESULTS: Haemoglobin (HGB) (P < 0.0001), haematocrit (HCT) (P < 0.0001), mean cell volume (MCV) (P = 0.0053), mean cell haemoglobin (MCH) (P < 0.0001), and mean cell haemoglobin concentration (MCHC) (P = 0.005) levels were reduced in cases compared to controls. Mixed cell percentage (MXD) (P = 0.018) and red blood cell distribution width (RDW-CV) (P = 0.012) were significantly elevated among cases as compared to controls. Haematuria was a clinical characteristic of heavy infection. CONCLUSION: S. haematobium infection creates an imbalance in the haematological profile. We found low HGB, HCT, MCV, MCH, and MCHC levels coupled with increased % MXD count and RDW-CV. Also, low MCV, MCH, and MCHC and high % MXD count are independently associated with S. haematobium infection among our study participants.
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spelling pubmed-54976442017-07-16 Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children Afrifa, Justice Gyedu, Desmond Ofori Gyamerah, Eric Essien-Baidoo, Samuel Mensah-Essilfie, Isaac J Environ Public Health Research Article BACKGROUND: Urogenital schistosomiasis is a widely contracted parasitic helminth infection often associated with haematological abnormalities. AIM: We investigated the relationship between the haematological profile and the intensity of schistosomiasis among children in the Yeji district. MATERIALS AND METHODS: A total of 100 participants comprising 50 Schistosoma haematobium (S. haematobium) infected and 50 noninfected controls aged 6–17 years matched for age and sex were recruited into the study. Blood and urine samples were collected and haematological profile and presence of S. haematobium eggs were assessed using standard protocols. RESULTS: Haemoglobin (HGB) (P < 0.0001), haematocrit (HCT) (P < 0.0001), mean cell volume (MCV) (P = 0.0053), mean cell haemoglobin (MCH) (P < 0.0001), and mean cell haemoglobin concentration (MCHC) (P = 0.005) levels were reduced in cases compared to controls. Mixed cell percentage (MXD) (P = 0.018) and red blood cell distribution width (RDW-CV) (P = 0.012) were significantly elevated among cases as compared to controls. Haematuria was a clinical characteristic of heavy infection. CONCLUSION: S. haematobium infection creates an imbalance in the haematological profile. We found low HGB, HCT, MCV, MCH, and MCHC levels coupled with increased % MXD count and RDW-CV. Also, low MCV, MCH, and MCHC and high % MXD count are independently associated with S. haematobium infection among our study participants. Hindawi 2017 2017-06-21 /pmc/articles/PMC5497644/ /pubmed/28713432 http://dx.doi.org/10.1155/2017/4248325 Text en Copyright © 2017 Justice Afrifa et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Afrifa, Justice
Gyedu, Desmond
Ofori Gyamerah, Eric
Essien-Baidoo, Samuel
Mensah-Essilfie, Isaac
Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title_full Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title_fullStr Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title_full_unstemmed Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title_short Haematological Profile and Intensity of Urogenital Schistosomiasis in Ghanaian Children
title_sort haematological profile and intensity of urogenital schistosomiasis in ghanaian children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497644/
https://www.ncbi.nlm.nih.gov/pubmed/28713432
http://dx.doi.org/10.1155/2017/4248325
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