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Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are gene...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497801/ https://www.ncbi.nlm.nih.gov/pubmed/28421697 http://dx.doi.org/10.1111/cas.13262 |
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author | Shangguan, Wenqi Fan, Chuanwen Chen, Xiaolong Lu, Ran Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Mo, Xianming |
author_facet | Shangguan, Wenqi Fan, Chuanwen Chen, Xiaolong Lu, Ran Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Mo, Xianming |
author_sort | Shangguan, Wenqi |
collection | PubMed |
description | Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are generated from glioblastoma stem cells is largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues. Here we show that cancer stem cells of human colorectal carcinomas (CoCSC) can give rise to vascular endothelial cells and compose the vasculatures in cancer tissues. The human‐cell‐specific nuclear antigen NuMA (+) vascular endothelial cells were detected in the blood vessels in xenografts derived from CoCSC. NuMA (+) endothelial cells incorporated into functional blood vessels. Our data indicate that the cancer stem cells derived from human colorectal carcinomas have the capacity to generate functional blood vessels and provide a new mechanism for tumor vasculogenesis in carcinoma. |
format | Online Article Text |
id | pubmed-5497801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54978012017-07-10 Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels Shangguan, Wenqi Fan, Chuanwen Chen, Xiaolong Lu, Ran Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Mo, Xianming Cancer Sci Original Articles Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are generated from glioblastoma stem cells is largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues. Here we show that cancer stem cells of human colorectal carcinomas (CoCSC) can give rise to vascular endothelial cells and compose the vasculatures in cancer tissues. The human‐cell‐specific nuclear antigen NuMA (+) vascular endothelial cells were detected in the blood vessels in xenografts derived from CoCSC. NuMA (+) endothelial cells incorporated into functional blood vessels. Our data indicate that the cancer stem cells derived from human colorectal carcinomas have the capacity to generate functional blood vessels and provide a new mechanism for tumor vasculogenesis in carcinoma. John Wiley and Sons Inc. 2017-07-04 2017-07 /pmc/articles/PMC5497801/ /pubmed/28421697 http://dx.doi.org/10.1111/cas.13262 Text en © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Shangguan, Wenqi Fan, Chuanwen Chen, Xiaolong Lu, Ran Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Mo, Xianming Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title | Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title_full | Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title_fullStr | Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title_full_unstemmed | Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title_short | Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
title_sort | endothelium originated from colorectal cancer stem cells constitute cancer blood vessels |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497801/ https://www.ncbi.nlm.nih.gov/pubmed/28421697 http://dx.doi.org/10.1111/cas.13262 |
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