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Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels

Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are gene...

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Autores principales: Shangguan, Wenqi, Fan, Chuanwen, Chen, Xiaolong, Lu, Ran, Liu, Yuan, Li, Yu, Shang, Yanna, Yin, Dongqin, Zhang, Shengliang, Huang, Qiaorong, Li, Xue, Meng, Wentong, Xu, Hong, Zhou, Zongguang, Hu, Jiankun, Mo, Xianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497801/
https://www.ncbi.nlm.nih.gov/pubmed/28421697
http://dx.doi.org/10.1111/cas.13262
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author Shangguan, Wenqi
Fan, Chuanwen
Chen, Xiaolong
Lu, Ran
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Mo, Xianming
author_facet Shangguan, Wenqi
Fan, Chuanwen
Chen, Xiaolong
Lu, Ran
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Mo, Xianming
author_sort Shangguan, Wenqi
collection PubMed
description Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are generated from glioblastoma stem cells is largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues. Here we show that cancer stem cells of human colorectal carcinomas (CoCSC) can give rise to vascular endothelial cells and compose the vasculatures in cancer tissues. The human‐cell‐specific nuclear antigen NuMA (+) vascular endothelial cells were detected in the blood vessels in xenografts derived from CoCSC. NuMA (+) endothelial cells incorporated into functional blood vessels. Our data indicate that the cancer stem cells derived from human colorectal carcinomas have the capacity to generate functional blood vessels and provide a new mechanism for tumor vasculogenesis in carcinoma.
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spelling pubmed-54978012017-07-10 Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels Shangguan, Wenqi Fan, Chuanwen Chen, Xiaolong Lu, Ran Liu, Yuan Li, Yu Shang, Yanna Yin, Dongqin Zhang, Shengliang Huang, Qiaorong Li, Xue Meng, Wentong Xu, Hong Zhou, Zongguang Hu, Jiankun Mo, Xianming Cancer Sci Original Articles Tumor growth depends on the formation of blood vessels that provide the supply of nutrients and oxygen. Previous data have shown that glioblastoma stem cells are able to give rise to vascular cells to constitute the functional vessels in tumor tissues. However, which kinds of vascular cells are generated from glioblastoma stem cells is largely debated. In addition, there is little evidence showing that the stem cells from other kinds of tumors can produce vascular cells to constitute the functional blood vessels in tumor tissues. Here we show that cancer stem cells of human colorectal carcinomas (CoCSC) can give rise to vascular endothelial cells and compose the vasculatures in cancer tissues. The human‐cell‐specific nuclear antigen NuMA (+) vascular endothelial cells were detected in the blood vessels in xenografts derived from CoCSC. NuMA (+) endothelial cells incorporated into functional blood vessels. Our data indicate that the cancer stem cells derived from human colorectal carcinomas have the capacity to generate functional blood vessels and provide a new mechanism for tumor vasculogenesis in carcinoma. John Wiley and Sons Inc. 2017-07-04 2017-07 /pmc/articles/PMC5497801/ /pubmed/28421697 http://dx.doi.org/10.1111/cas.13262 Text en © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Shangguan, Wenqi
Fan, Chuanwen
Chen, Xiaolong
Lu, Ran
Liu, Yuan
Li, Yu
Shang, Yanna
Yin, Dongqin
Zhang, Shengliang
Huang, Qiaorong
Li, Xue
Meng, Wentong
Xu, Hong
Zhou, Zongguang
Hu, Jiankun
Mo, Xianming
Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title_full Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title_fullStr Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title_full_unstemmed Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title_short Endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
title_sort endothelium originated from colorectal cancer stem cells constitute cancer blood vessels
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497801/
https://www.ncbi.nlm.nih.gov/pubmed/28421697
http://dx.doi.org/10.1111/cas.13262
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