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A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients
BACKGROUND: Given the expected increase in the number of elderly recipients, details regarding how clinical factors influence the outcome in living donor liver transplantation (LDLT) for the elderly remain unclear. We examined the survival outcomes according to the results of donor age-based and gra...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498009/ https://www.ncbi.nlm.nih.gov/pubmed/28706971 http://dx.doi.org/10.1097/TXD.0000000000000688 |
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author | Imamura, Hajime Hidaka, Masaaki Soyama, Akihiko Kitasato, Amane Adachi, Tomohiko Ono, Shinichiro Natsuda, Koji Hara, Takanobu Kugiyama, Tota Baimakhanov, Zhassulan Okada, Satomi Fujita, Fumihiko Kanetaka, Kengo Takatsuki, Mitsuhisa Kuroki, Tamotsu Eguchi, Susumu |
author_facet | Imamura, Hajime Hidaka, Masaaki Soyama, Akihiko Kitasato, Amane Adachi, Tomohiko Ono, Shinichiro Natsuda, Koji Hara, Takanobu Kugiyama, Tota Baimakhanov, Zhassulan Okada, Satomi Fujita, Fumihiko Kanetaka, Kengo Takatsuki, Mitsuhisa Kuroki, Tamotsu Eguchi, Susumu |
author_sort | Imamura, Hajime |
collection | PubMed |
description | BACKGROUND: Given the expected increase in the number of elderly recipients, details regarding how clinical factors influence the outcome in living donor liver transplantation (LDLT) for the elderly remain unclear. We examined the survival outcomes according to the results of donor age-based and graft volume–based analyses and assessed the impact of prognostic factors on the survival after LDLT for elderly recipients. METHODS: The 198 adult recipients were classified into 2 groups: an elderly group (n = 70, E group; ≥ 60 years of age) and a younger group (n = 128, Y group; <60 years of age). We analyzed the prognostic factors for the survival in the E group and the survival rate for both groups at several follow-up points and conducted subgroup analyses in the E group by combining the donor age (≥50 vs <50 years) and graft weight (GW)/standard liver volume (SLV) (≥40% vs <40%). RESULTS: Donor age (hazard ratio [HR], 2.17; P = 0.062) and GW/SLV (HR, 1.80; P = 0.23) tended to have a high HR in the E group. The overall patient survival rates at 1, 3, and 5 years were 78.3%, 73.0%, and 61.0% in the E group, and 82.0%, 75.1%, and 69.2% in the Y group, respectively (P = 0.459). However, the outcomes tended to be worse in recipients of grafts from donors ≥50 years of age than in those with grafts from younger donors with GW/SLV < 40% (P = 0.048). CONCLUSIONS: A worse outcome might be associated with aging of the donor, which leads to impairment of the graft function and liver regeneration. Both the graft volume and donor age should be considered when choosing grafts for LDLT in elderly patients. |
format | Online Article Text |
id | pubmed-5498009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-54980092017-07-13 A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients Imamura, Hajime Hidaka, Masaaki Soyama, Akihiko Kitasato, Amane Adachi, Tomohiko Ono, Shinichiro Natsuda, Koji Hara, Takanobu Kugiyama, Tota Baimakhanov, Zhassulan Okada, Satomi Fujita, Fumihiko Kanetaka, Kengo Takatsuki, Mitsuhisa Kuroki, Tamotsu Eguchi, Susumu Transplant Direct Liver Transplantation BACKGROUND: Given the expected increase in the number of elderly recipients, details regarding how clinical factors influence the outcome in living donor liver transplantation (LDLT) for the elderly remain unclear. We examined the survival outcomes according to the results of donor age-based and graft volume–based analyses and assessed the impact of prognostic factors on the survival after LDLT for elderly recipients. METHODS: The 198 adult recipients were classified into 2 groups: an elderly group (n = 70, E group; ≥ 60 years of age) and a younger group (n = 128, Y group; <60 years of age). We analyzed the prognostic factors for the survival in the E group and the survival rate for both groups at several follow-up points and conducted subgroup analyses in the E group by combining the donor age (≥50 vs <50 years) and graft weight (GW)/standard liver volume (SLV) (≥40% vs <40%). RESULTS: Donor age (hazard ratio [HR], 2.17; P = 0.062) and GW/SLV (HR, 1.80; P = 0.23) tended to have a high HR in the E group. The overall patient survival rates at 1, 3, and 5 years were 78.3%, 73.0%, and 61.0% in the E group, and 82.0%, 75.1%, and 69.2% in the Y group, respectively (P = 0.459). However, the outcomes tended to be worse in recipients of grafts from donors ≥50 years of age than in those with grafts from younger donors with GW/SLV < 40% (P = 0.048). CONCLUSIONS: A worse outcome might be associated with aging of the donor, which leads to impairment of the graft function and liver regeneration. Both the graft volume and donor age should be considered when choosing grafts for LDLT in elderly patients. Lippincott Williams & Wilkins 2017-06-06 /pmc/articles/PMC5498009/ /pubmed/28706971 http://dx.doi.org/10.1097/TXD.0000000000000688 Text en Copyright © 2017 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Liver Transplantation Imamura, Hajime Hidaka, Masaaki Soyama, Akihiko Kitasato, Amane Adachi, Tomohiko Ono, Shinichiro Natsuda, Koji Hara, Takanobu Kugiyama, Tota Baimakhanov, Zhassulan Okada, Satomi Fujita, Fumihiko Kanetaka, Kengo Takatsuki, Mitsuhisa Kuroki, Tamotsu Eguchi, Susumu A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title | A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title_full | A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title_fullStr | A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title_full_unstemmed | A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title_short | A Donor Age-Based and Graft Volume–Based Analysis for Living Donor Liver Transplantation in Elderly Recipients |
title_sort | donor age-based and graft volume–based analysis for living donor liver transplantation in elderly recipients |
topic | Liver Transplantation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498009/ https://www.ncbi.nlm.nih.gov/pubmed/28706971 http://dx.doi.org/10.1097/TXD.0000000000000688 |
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