An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient

An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B(1...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujita, Shingo, Kozawa, Junji, Ishibashi, Chisaki, Kimura, Takekazu, Kitamura, Tetsuhiro, Fukui, Kenji, Yasuda, Tetsuyuki, Iwahashi, Hiromi, Imagawa, Akihisa, Shimomura, Iichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498203/
https://www.ncbi.nlm.nih.gov/pubmed/28566602
http://dx.doi.org/10.2169/internalmedicine.56.8489
_version_ 1783248270279049216
author Fujita, Shingo
Kozawa, Junji
Ishibashi, Chisaki
Kimura, Takekazu
Kitamura, Tetsuhiro
Fukui, Kenji
Yasuda, Tetsuyuki
Iwahashi, Hiromi
Imagawa, Akihisa
Shimomura, Iichiro
author_facet Fujita, Shingo
Kozawa, Junji
Ishibashi, Chisaki
Kimura, Takekazu
Kitamura, Tetsuhiro
Fukui, Kenji
Yasuda, Tetsuyuki
Iwahashi, Hiromi
Imagawa, Akihisa
Shimomura, Iichiro
author_sort Fujita, Shingo
collection PubMed
description An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B(12) deficiency is also associated with the dysfunction of central nervous system. We report a 72-year-old type 1 diabetic patient with vitamin B(12) deficiency whose impaired awareness of hypoglycemia improved after 4 weeks of vitamin B(12) administration with an increased counter-hormone secretion in response to hypoglycemia. We should recognize vitamin B(12) deficiency as one of the causes of an impaired awareness of hypoglycemia in diabetic patients.
format Online
Article
Text
id pubmed-5498203
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-54982032017-07-07 An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient Fujita, Shingo Kozawa, Junji Ishibashi, Chisaki Kimura, Takekazu Kitamura, Tetsuhiro Fukui, Kenji Yasuda, Tetsuyuki Iwahashi, Hiromi Imagawa, Akihisa Shimomura, Iichiro Intern Med Case Report An impaired awareness of hypoglycemia is a serious problem in diabetic patients, which can lead to life-threatening severe hypoglycemia. Recurrent hypoglycemia attenuates the function of the central, mainly hypothalamic, nervous system and it causes an impaired awareness of hypoglycemia. Vitamin B(12) deficiency is also associated with the dysfunction of central nervous system. We report a 72-year-old type 1 diabetic patient with vitamin B(12) deficiency whose impaired awareness of hypoglycemia improved after 4 weeks of vitamin B(12) administration with an increased counter-hormone secretion in response to hypoglycemia. We should recognize vitamin B(12) deficiency as one of the causes of an impaired awareness of hypoglycemia in diabetic patients. The Japanese Society of Internal Medicine 2017-06-01 /pmc/articles/PMC5498203/ /pubmed/28566602 http://dx.doi.org/10.2169/internalmedicine.56.8489 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fujita, Shingo
Kozawa, Junji
Ishibashi, Chisaki
Kimura, Takekazu
Kitamura, Tetsuhiro
Fukui, Kenji
Yasuda, Tetsuyuki
Iwahashi, Hiromi
Imagawa, Akihisa
Shimomura, Iichiro
An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title_full An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title_fullStr An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title_full_unstemmed An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title_short An Impaired Awareness of Hypoglycemia Improved After Vitamin B(12) Treatment in a Type 1 Diabetic Patient
title_sort impaired awareness of hypoglycemia improved after vitamin b(12) treatment in a type 1 diabetic patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498203/
https://www.ncbi.nlm.nih.gov/pubmed/28566602
http://dx.doi.org/10.2169/internalmedicine.56.8489
work_keys_str_mv AT fujitashingo animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kozawajunji animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT ishibashichisaki animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kimuratakekazu animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kitamuratetsuhiro animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT fukuikenji animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT yasudatetsuyuki animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT iwahashihiromi animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT imagawaakihisa animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT shimomuraiichiro animpairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT fujitashingo impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kozawajunji impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT ishibashichisaki impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kimuratakekazu impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT kitamuratetsuhiro impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT fukuikenji impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT yasudatetsuyuki impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT iwahashihiromi impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT imagawaakihisa impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient
AT shimomuraiichiro impairedawarenessofhypoglycemiaimprovedaftervitaminb12treatmentinatype1diabeticpatient

Ejemplares similares