Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis

A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the dia...

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Autores principales: Imai, Ayano, Takase, Hiroshi, Imadome, Ken-Ichi, Matsuda, Go, Ohnishi, Iichiro, Yamamoto, Kouhei, Kudo, Takumi, Tanaka, Yoji, Maehara, Taketoshi, Miura, Osamu, Arai, Ayako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498208/
https://www.ncbi.nlm.nih.gov/pubmed/28566607
http://dx.doi.org/10.2169/internalmedicine.56.7573
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author Imai, Ayano
Takase, Hiroshi
Imadome, Ken-Ichi
Matsuda, Go
Ohnishi, Iichiro
Yamamoto, Kouhei
Kudo, Takumi
Tanaka, Yoji
Maehara, Taketoshi
Miura, Osamu
Arai, Ayako
author_facet Imai, Ayano
Takase, Hiroshi
Imadome, Ken-Ichi
Matsuda, Go
Ohnishi, Iichiro
Yamamoto, Kouhei
Kudo, Takumi
Tanaka, Yoji
Maehara, Taketoshi
Miura, Osamu
Arai, Ayako
author_sort Imai, Ayano
collection PubMed
description A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1, an EBV gene, detected in the brain lesion was identical to that detected in the vitreous fluid. ENKL of the central nervous system is quite rare, and the pathogenesis has not been determined. The lymphoma in this case might have been closely associated with the EBV-positive uveitis.
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spelling pubmed-54982082017-07-07 Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis Imai, Ayano Takase, Hiroshi Imadome, Ken-Ichi Matsuda, Go Ohnishi, Iichiro Yamamoto, Kouhei Kudo, Takumi Tanaka, Yoji Maehara, Taketoshi Miura, Osamu Arai, Ayako Intern Med Case Report A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Four years after the onset, T2-weighted contrast-enhanced MRI revealed hyperintense lesions in the right occipital and parietal lobe. A biopsy resulted in the diagnosis of extranodal NK/T-cell lymphoma nasal type (ENKL). The repeat region of LMP1, an EBV gene, detected in the brain lesion was identical to that detected in the vitreous fluid. ENKL of the central nervous system is quite rare, and the pathogenesis has not been determined. The lymphoma in this case might have been closely associated with the EBV-positive uveitis. The Japanese Society of Internal Medicine 2017-06-01 /pmc/articles/PMC5498208/ /pubmed/28566607 http://dx.doi.org/10.2169/internalmedicine.56.7573 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Imai, Ayano
Takase, Hiroshi
Imadome, Ken-Ichi
Matsuda, Go
Ohnishi, Iichiro
Yamamoto, Kouhei
Kudo, Takumi
Tanaka, Yoji
Maehara, Taketoshi
Miura, Osamu
Arai, Ayako
Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title_full Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title_fullStr Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title_full_unstemmed Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title_short Development of Extranodal NK/T-cell Lymphoma Nasal Type in Cerebrum Following Epstein-Barr Virus-positive Uveitis
title_sort development of extranodal nk/t-cell lymphoma nasal type in cerebrum following epstein-barr virus-positive uveitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498208/
https://www.ncbi.nlm.nih.gov/pubmed/28566607
http://dx.doi.org/10.2169/internalmedicine.56.7573
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