The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab

Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various im...

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Detalles Bibliográficos
Autores principales: Matsuo, Satoko, Hayashi, Keigo, Morimoto, Eisaku, Kato, Ayako, Sada, Ken-Ei, Watanabe, Haruki, Takano-Narazaki, Mariko, Sunahori-Watanabe, Katsue, Kawabata, Tomoko, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498213/
https://www.ncbi.nlm.nih.gov/pubmed/28566612
http://dx.doi.org/10.2169/internalmedicine.56.8235
Descripción
Sumario:Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various immunosuppressive treatments, including cyclophosphamide, methotrexate, and rituximab. After infliximab (IFX) treatment was initiated, his symptoms improved dramatically and remission was maintained. IFX is considered to be an effective alternative treatment for PAN which proves to be refractory to several immunosuppressive treatments.

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