The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab

Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various im...

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Autores principales: Matsuo, Satoko, Hayashi, Keigo, Morimoto, Eisaku, Kato, Ayako, Sada, Ken-Ei, Watanabe, Haruki, Takano-Narazaki, Mariko, Sunahori-Watanabe, Katsue, Kawabata, Tomoko, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498213/
https://www.ncbi.nlm.nih.gov/pubmed/28566612
http://dx.doi.org/10.2169/internalmedicine.56.8235
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author Matsuo, Satoko
Hayashi, Keigo
Morimoto, Eisaku
Kato, Ayako
Sada, Ken-Ei
Watanabe, Haruki
Takano-Narazaki, Mariko
Sunahori-Watanabe, Katsue
Kawabata, Tomoko
Wada, Jun
author_facet Matsuo, Satoko
Hayashi, Keigo
Morimoto, Eisaku
Kato, Ayako
Sada, Ken-Ei
Watanabe, Haruki
Takano-Narazaki, Mariko
Sunahori-Watanabe, Katsue
Kawabata, Tomoko
Wada, Jun
author_sort Matsuo, Satoko
collection PubMed
description Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various immunosuppressive treatments, including cyclophosphamide, methotrexate, and rituximab. After infliximab (IFX) treatment was initiated, his symptoms improved dramatically and remission was maintained. IFX is considered to be an effective alternative treatment for PAN which proves to be refractory to several immunosuppressive treatments.
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spelling pubmed-54982132017-07-07 The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab Matsuo, Satoko Hayashi, Keigo Morimoto, Eisaku Kato, Ayako Sada, Ken-Ei Watanabe, Haruki Takano-Narazaki, Mariko Sunahori-Watanabe, Katsue Kawabata, Tomoko Wada, Jun Intern Med Case Report Polyarteritis nodosa (PAN), characterized by arteritis of medium-sized blood vessels, is usually treated with a combination of glucocorticoids and immunosuppressants; however, some cases are refractory to these treatments. We herein report the case of a man with PAN that was refractory to various immunosuppressive treatments, including cyclophosphamide, methotrexate, and rituximab. After infliximab (IFX) treatment was initiated, his symptoms improved dramatically and remission was maintained. IFX is considered to be an effective alternative treatment for PAN which proves to be refractory to several immunosuppressive treatments. The Japanese Society of Internal Medicine 2017-06-01 /pmc/articles/PMC5498213/ /pubmed/28566612 http://dx.doi.org/10.2169/internalmedicine.56.8235 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsuo, Satoko
Hayashi, Keigo
Morimoto, Eisaku
Kato, Ayako
Sada, Ken-Ei
Watanabe, Haruki
Takano-Narazaki, Mariko
Sunahori-Watanabe, Katsue
Kawabata, Tomoko
Wada, Jun
The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title_full The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title_fullStr The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title_full_unstemmed The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title_short The Successful Treatment of Refractory Polyarteritis Nodosa Using Infliximab
title_sort successful treatment of refractory polyarteritis nodosa using infliximab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498213/
https://www.ncbi.nlm.nih.gov/pubmed/28566612
http://dx.doi.org/10.2169/internalmedicine.56.8235
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