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Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015
Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya. During 2014–2015, 730 patients were screened for anti-F. tularen...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498284/ https://www.ncbi.nlm.nih.gov/pubmed/28721222 http://dx.doi.org/10.1016/j.nmni.2017.05.015 |
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author | Njeru, J. Tomaso, H. Mertens, K. Henning, K. Wareth, G. Heller, R. Kariuki, S. Fèvre, E.M. Neubauer, H. Pletz, M.W. |
author_facet | Njeru, J. Tomaso, H. Mertens, K. Henning, K. Wareth, G. Heller, R. Kariuki, S. Fèvre, E.M. Neubauer, H. Pletz, M.W. |
author_sort | Njeru, J. |
collection | PubMed |
description | Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya. During 2014–2015, 730 patients were screened for anti-F. tularensis antibodies using a combination of ELISA and Western blot. Twenty-seven (3.7%) individuals were positive for F. tularensis. Tularaemia was not suspected by the treating clinicians in any of them. Our results suggest that tularaemia may be present in Kenya but remain unreported, and emphasizes the need for local clinicians to broaden their diagnostic repertoire when evaluating patients with undifferentiated febrile illness. |
format | Online Article Text |
id | pubmed-5498284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54982842017-07-18 Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 Njeru, J. Tomaso, H. Mertens, K. Henning, K. Wareth, G. Heller, R. Kariuki, S. Fèvre, E.M. Neubauer, H. Pletz, M.W. New Microbes New Infect Original Article Tularaemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. The aim of this study was to investigate the presence of antibodies to F. tularensis in febrile patients in northeastern Kenya. During 2014–2015, 730 patients were screened for anti-F. tularensis antibodies using a combination of ELISA and Western blot. Twenty-seven (3.7%) individuals were positive for F. tularensis. Tularaemia was not suspected by the treating clinicians in any of them. Our results suggest that tularaemia may be present in Kenya but remain unreported, and emphasizes the need for local clinicians to broaden their diagnostic repertoire when evaluating patients with undifferentiated febrile illness. Elsevier 2017-06-03 /pmc/articles/PMC5498284/ /pubmed/28721222 http://dx.doi.org/10.1016/j.nmni.2017.05.015 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Njeru, J. Tomaso, H. Mertens, K. Henning, K. Wareth, G. Heller, R. Kariuki, S. Fèvre, E.M. Neubauer, H. Pletz, M.W. Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title | Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title_full | Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title_fullStr | Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title_full_unstemmed | Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title_short | Serological evidence of Francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern Kenya, 2014–2015 |
title_sort | serological evidence of francisella tularensis in febrile patients seeking treatment at remote hospitals, northeastern kenya, 2014–2015 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498284/ https://www.ncbi.nlm.nih.gov/pubmed/28721222 http://dx.doi.org/10.1016/j.nmni.2017.05.015 |
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