An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection

Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car(91) that was attenuated in guinea pigs. Infection of guinea pigs with an earlier passage of Carvallo, termed Car(68), resulted...

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Detalles Bibliográficos
Autores principales: Golden, Joseph W., Beitzel, Brett, Ladner, Jason T., Mucker, Eric M., Kwilas, Steven A., Palacios, Gustavo, Hooper, Jay W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498534/
https://www.ncbi.nlm.nih.gov/pubmed/28680057
http://dx.doi.org/10.1038/s41598-017-04889-x

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