N-[(11)C]Methyl-AMD3465 PET as a Tool for In Vivo Measurement of Chemokine Receptor 4 (CXCR4) Occupancy by Therapeutic Drugs

PURPOSE: Chemokine receptor 4 (CXCR4) is overexpressed in many cancers and a potential drug target. We have recently developed the tracer N-[(11)C]methyl-AMD3465 for imaging of CXCR4 expression by positron emission tomography (PET). We investigated the pharmacokinetics of N-[(11)C]methyl-AMD3465 in...

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Detalles Bibliográficos
Autores principales: Hartimath, S. V., Khayum, M. A., van Waarde, A., Dierckx, R. A. J. O., de Vries, E. F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498639/
https://www.ncbi.nlm.nih.gov/pubmed/27896627
http://dx.doi.org/10.1007/s11307-016-1028-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498639/
https://www.ncbi.nlm.nih.gov/pubmed/27896627
http://dx.doi.org/10.1007/s11307-016-1028-8

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