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The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women

BACKGROUND: Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown. AIM: To determine GBS colonization prevalence and its risk factors among Ir...

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Autores principales: Darabi, Roksana, Tadi, Sima, Mohit, Mitra, Sadeghi, Erfan, Hatamizadeh, Gita, Kardeh, Bahareh, Etminan-Bakhsh, Mina, Parsa, Yekta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Electronic physician 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498706/
https://www.ncbi.nlm.nih.gov/pubmed/28713513
http://dx.doi.org/10.19082/4399
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author Darabi, Roksana
Tadi, Sima
Mohit, Mitra
Sadeghi, Erfan
Hatamizadeh, Gita
Kardeh, Bahareh
Etminan-Bakhsh, Mina
Parsa, Yekta
author_facet Darabi, Roksana
Tadi, Sima
Mohit, Mitra
Sadeghi, Erfan
Hatamizadeh, Gita
Kardeh, Bahareh
Etminan-Bakhsh, Mina
Parsa, Yekta
author_sort Darabi, Roksana
collection PubMed
description BACKGROUND: Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown. AIM: To determine GBS colonization prevalence and its risk factors among Iranian pregnant women. METHODS: This prospective cross-sectional study was performed on 186 pregnant women, who attended Boo-Ali hospital which is affiliated with Islamic Azad University in Tehran, Iran, from March 2014 to June 2015. The demographic, obstetric and gynecological data were gathered. A recto-vaginal culture was taken from each patient, with a sterile swab, in lithotomy position without using speculum, and vaginal pH was measured. Patients with positive GBS received IV antibiotic therapy during labor (penicillin G 3 gram at first dose then 1.5 gram Q/4h until delivery). Data were analyzed by statistical software SPSS version 21. Statistical tests for differences were performed by Chi-square test. Potential confounding was assessed by logistic regression. Level of significance was set at p<0.05. RESULTS: Twenty-two (11.8%) patients had positive recto-vaginal colonization. No significant differences between colonized and GBS-negative women with regard to age, obstetrics history and socio-economic factor were noticed. In contrast, smoking, history of previous infection with HPV, presence of vulvitis and a vaginal pH>4.5 were associated with GBS colonization (p≤0.05). CONCLUSIONS: With a relatively low prevalence and few significantly correlated factors, it is hardly possible to define a high risk group of pregnant women for GBS colonization. Therefore, thorough measures should be taken in order to prevent infection complications in mothers and neonates in the Iranian population.
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spelling pubmed-54987062017-07-14 The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women Darabi, Roksana Tadi, Sima Mohit, Mitra Sadeghi, Erfan Hatamizadeh, Gita Kardeh, Bahareh Etminan-Bakhsh, Mina Parsa, Yekta Electron Physician Original Article BACKGROUND: Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown. AIM: To determine GBS colonization prevalence and its risk factors among Iranian pregnant women. METHODS: This prospective cross-sectional study was performed on 186 pregnant women, who attended Boo-Ali hospital which is affiliated with Islamic Azad University in Tehran, Iran, from March 2014 to June 2015. The demographic, obstetric and gynecological data were gathered. A recto-vaginal culture was taken from each patient, with a sterile swab, in lithotomy position without using speculum, and vaginal pH was measured. Patients with positive GBS received IV antibiotic therapy during labor (penicillin G 3 gram at first dose then 1.5 gram Q/4h until delivery). Data were analyzed by statistical software SPSS version 21. Statistical tests for differences were performed by Chi-square test. Potential confounding was assessed by logistic regression. Level of significance was set at p<0.05. RESULTS: Twenty-two (11.8%) patients had positive recto-vaginal colonization. No significant differences between colonized and GBS-negative women with regard to age, obstetrics history and socio-economic factor were noticed. In contrast, smoking, history of previous infection with HPV, presence of vulvitis and a vaginal pH>4.5 were associated with GBS colonization (p≤0.05). CONCLUSIONS: With a relatively low prevalence and few significantly correlated factors, it is hardly possible to define a high risk group of pregnant women for GBS colonization. Therefore, thorough measures should be taken in order to prevent infection complications in mothers and neonates in the Iranian population. Electronic physician 2017-05-25 /pmc/articles/PMC5498706/ /pubmed/28713513 http://dx.doi.org/10.19082/4399 Text en © 2017 The Authors This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Original Article
Darabi, Roksana
Tadi, Sima
Mohit, Mitra
Sadeghi, Erfan
Hatamizadeh, Gita
Kardeh, Bahareh
Etminan-Bakhsh, Mina
Parsa, Yekta
The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title_full The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title_fullStr The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title_full_unstemmed The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title_short The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women
title_sort prevalence and risk factors of group b streptococcus colonization in iranian pregnant women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498706/
https://www.ncbi.nlm.nih.gov/pubmed/28713513
http://dx.doi.org/10.19082/4399
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