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Development of a Novel Virus-Like Particle Vaccine Platform That Mimics the Immature Form of Alphavirus
Virus-like particles (VLPs) are noninfectious multiprotein structures that are engineered to self-assemble from viral structural proteins. Here, we developed a novel VLP-based vaccine platform utilizing VLPs from the chikungunya virus. We identified two regions within the envelope protein, a structu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498722/ https://www.ncbi.nlm.nih.gov/pubmed/28515133 http://dx.doi.org/10.1128/CVI.00090-17 |