Identification of inhibitors against α-Isopropylmalate Synthase of Mycobacterium tuberculosis using docking-MM/PBSA hybrid approach

α-Isopropylmalate Synthase (α-IPMS) encoded by leuA in Mycobacterium tuberculosis (M.tb) is involved in the leucine biosynthesis pathway and is extremely critical for the synthesis of branched-chain amino acids (leucine, isoleucine and valine). α-IPMS activity is required not only for the proliferat...

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Detalles Bibliográficos
Autores principales: Pandey, Preeti, Lynn, Andrew M., Bandyopadhyay, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2017
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498780/
https://www.ncbi.nlm.nih.gov/pubmed/28690380
http://dx.doi.org/10.6026/97320630013144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498780/
https://www.ncbi.nlm.nih.gov/pubmed/28690380
http://dx.doi.org/10.6026/97320630013144

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