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Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

BACKGROUND: A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage explants usi...

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Detalles Bibliográficos
Autores principales:	Swärd, Per, Wang, Yang, Hansson, Maria, Lohmander, L. Stefan, Grodzinsky, Alan J., Struglics, André
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498889/ https://www.ncbi.nlm.nih.gov/pubmed/28679445 http://dx.doi.org/10.1186/s13075-017-1318-9

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