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Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador

Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In t...

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Autores principales: Dalgo Aguilar, Paola, Loján González, Cisne, Córdova Rodríguez, Ana, Acurio Páez, Katherine, Arévalo, Ana Paulina, Bobokova, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498899/
https://www.ncbi.nlm.nih.gov/pubmed/28717342
http://dx.doi.org/10.1155/2017/8572065
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author Dalgo Aguilar, Paola
Loján González, Cisne
Córdova Rodríguez, Ana
Acurio Páez, Katherine
Arévalo, Ana Paulina
Bobokova, Jana
author_facet Dalgo Aguilar, Paola
Loján González, Cisne
Córdova Rodríguez, Ana
Acurio Páez, Katherine
Arévalo, Ana Paulina
Bobokova, Jana
author_sort Dalgo Aguilar, Paola
collection PubMed
description Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In the present investigation, the prevalence of high-risk HPV was determined from samples of premalignant or malignant cervical cytology in women from the southern region of Ecuador. The kit we used was able to detect genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. In addition, 64.5% of the analyzed samples were positive for HPV, with genotypes 16 and 18 being the most prevalent (16 was detected in 148 samples and 18 in 108). Genotypes 58 and 51 were the third most frequent simple and multiple infections, respectively. The data are very similar to those obtained worldwide, suggesting that the strategy of sex education, and the use of vaccines as primary prevention agents, could significantly decrease the incidence and mortality rate of cervical cancer in the southern region of Ecuador.
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spelling pubmed-54988992017-07-17 Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador Dalgo Aguilar, Paola Loján González, Cisne Córdova Rodríguez, Ana Acurio Páez, Katherine Arévalo, Ana Paulina Bobokova, Jana Infect Dis Obstet Gynecol Research Article Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In the present investigation, the prevalence of high-risk HPV was determined from samples of premalignant or malignant cervical cytology in women from the southern region of Ecuador. The kit we used was able to detect genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. In addition, 64.5% of the analyzed samples were positive for HPV, with genotypes 16 and 18 being the most prevalent (16 was detected in 148 samples and 18 in 108). Genotypes 58 and 51 were the third most frequent simple and multiple infections, respectively. The data are very similar to those obtained worldwide, suggesting that the strategy of sex education, and the use of vaccines as primary prevention agents, could significantly decrease the incidence and mortality rate of cervical cancer in the southern region of Ecuador. Hindawi 2017 2017-06-22 /pmc/articles/PMC5498899/ /pubmed/28717342 http://dx.doi.org/10.1155/2017/8572065 Text en Copyright © 2017 Paola Dalgo Aguilar et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dalgo Aguilar, Paola
Loján González, Cisne
Córdova Rodríguez, Ana
Acurio Páez, Katherine
Arévalo, Ana Paulina
Bobokova, Jana
Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title_full Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title_fullStr Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title_full_unstemmed Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title_short Prevalence of High-Risk Genotypes of Human Papillomavirus: Women Diagnosed with Premalignant and Malignant Pap Smear Tests in Southern Ecuador
title_sort prevalence of high-risk genotypes of human papillomavirus: women diagnosed with premalignant and malignant pap smear tests in southern ecuador
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498899/
https://www.ncbi.nlm.nih.gov/pubmed/28717342
http://dx.doi.org/10.1155/2017/8572065
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