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Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China

Compared to chemotherapy, promising results have been obtained by blocking the PD-1 pathway using antibodies that inhibit programmed cell death protein 1 (PD-1) or programmed cell death protein ligand 1 (PD-L1). Furthermore, global researchers and doctors are exploring how to optimize this immunothe...

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Autores principales: Liu, Si-Yang, Wu, Yi-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499002/
https://www.ncbi.nlm.nih.gov/pubmed/28679395
http://dx.doi.org/10.1186/s13045-017-0506-z
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author Liu, Si-Yang
Wu, Yi-Long
author_facet Liu, Si-Yang
Wu, Yi-Long
author_sort Liu, Si-Yang
collection PubMed
description Compared to chemotherapy, promising results have been obtained by blocking the PD-1 pathway using antibodies that inhibit programmed cell death protein 1 (PD-1) or programmed cell death protein ligand 1 (PD-L1). Furthermore, global researchers and doctors are exploring how to optimize this immunotherapy in 270 clinical studies. However, Chinese clinical trials of these agents remain in the early stages. We summarize the ongoing international and domestic clinical trials using PD-1 and PD-L1 inhibitors to treat lung cancer. This information can help researchers better understand the active and approved clinical trials in China, as well as the ongoing research regarding PD-1 and PD-L1 inhibitors.
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spelling pubmed-54990022017-07-10 Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China Liu, Si-Yang Wu, Yi-Long J Hematol Oncol Review Compared to chemotherapy, promising results have been obtained by blocking the PD-1 pathway using antibodies that inhibit programmed cell death protein 1 (PD-1) or programmed cell death protein ligand 1 (PD-L1). Furthermore, global researchers and doctors are exploring how to optimize this immunotherapy in 270 clinical studies. However, Chinese clinical trials of these agents remain in the early stages. We summarize the ongoing international and domestic clinical trials using PD-1 and PD-L1 inhibitors to treat lung cancer. This information can help researchers better understand the active and approved clinical trials in China, as well as the ongoing research regarding PD-1 and PD-L1 inhibitors. BioMed Central 2017-07-05 /pmc/articles/PMC5499002/ /pubmed/28679395 http://dx.doi.org/10.1186/s13045-017-0506-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Liu, Si-Yang
Wu, Yi-Long
Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title_full Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title_fullStr Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title_full_unstemmed Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title_short Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China
title_sort ongoing clinical trials of pd-1 and pd-l1 inhibitors for lung cancer in china
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499002/
https://www.ncbi.nlm.nih.gov/pubmed/28679395
http://dx.doi.org/10.1186/s13045-017-0506-z
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