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The COMET Handbook: version 1.0
The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to be relevant and important to key stakeholders including patients and the public...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499094/ https://www.ncbi.nlm.nih.gov/pubmed/28681707 http://dx.doi.org/10.1186/s13063-017-1978-4 |
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author | Williamson, Paula R. Altman, Douglas G. Bagley, Heather Barnes, Karen L. Blazeby, Jane M. Brookes, Sara T. Clarke, Mike Gargon, Elizabeth Gorst, Sarah Harman, Nicola Kirkham, Jamie J. McNair, Angus Prinsen, Cecilia A. C. Schmitt, Jochen Terwee, Caroline B. Young, Bridget |
author_facet | Williamson, Paula R. Altman, Douglas G. Bagley, Heather Barnes, Karen L. Blazeby, Jane M. Brookes, Sara T. Clarke, Mike Gargon, Elizabeth Gorst, Sarah Harman, Nicola Kirkham, Jamie J. McNair, Angus Prinsen, Cecilia A. C. Schmitt, Jochen Terwee, Caroline B. Young, Bridget |
author_sort | Williamson, Paula R. |
collection | PubMed |
description | The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. It is now widely acknowledged that insufficient attention has been paid to the choice of outcomes measured in clinical trials. Researchers are increasingly addressing this issue through the development and use of a core outcome set, an agreed standardised collection of outcomes which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for guidance on the development, implementation, evaluation and updating of core outcome sets. This Handbook, developed by the COMET Initiative, brings together current thinking and methodological research regarding those issues. We recommend a four-step process to develop a core outcome set. The aim is to update the contents of the Handbook as further research is identified. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13063-017-1978-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5499094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54990942017-07-10 The COMET Handbook: version 1.0 Williamson, Paula R. Altman, Douglas G. Bagley, Heather Barnes, Karen L. Blazeby, Jane M. Brookes, Sara T. Clarke, Mike Gargon, Elizabeth Gorst, Sarah Harman, Nicola Kirkham, Jamie J. McNair, Angus Prinsen, Cecilia A. C. Schmitt, Jochen Terwee, Caroline B. Young, Bridget Trials Review The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. It is now widely acknowledged that insufficient attention has been paid to the choice of outcomes measured in clinical trials. Researchers are increasingly addressing this issue through the development and use of a core outcome set, an agreed standardised collection of outcomes which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for guidance on the development, implementation, evaluation and updating of core outcome sets. This Handbook, developed by the COMET Initiative, brings together current thinking and methodological research regarding those issues. We recommend a four-step process to develop a core outcome set. The aim is to update the contents of the Handbook as further research is identified. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13063-017-1978-4) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-20 /pmc/articles/PMC5499094/ /pubmed/28681707 http://dx.doi.org/10.1186/s13063-017-1978-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Williamson, Paula R. Altman, Douglas G. Bagley, Heather Barnes, Karen L. Blazeby, Jane M. Brookes, Sara T. Clarke, Mike Gargon, Elizabeth Gorst, Sarah Harman, Nicola Kirkham, Jamie J. McNair, Angus Prinsen, Cecilia A. C. Schmitt, Jochen Terwee, Caroline B. Young, Bridget The COMET Handbook: version 1.0 |
title | The COMET Handbook: version 1.0 |
title_full | The COMET Handbook: version 1.0 |
title_fullStr | The COMET Handbook: version 1.0 |
title_full_unstemmed | The COMET Handbook: version 1.0 |
title_short | The COMET Handbook: version 1.0 |
title_sort | comet handbook: version 1.0 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499094/ https://www.ncbi.nlm.nih.gov/pubmed/28681707 http://dx.doi.org/10.1186/s13063-017-1978-4 |
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