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Experimental Evolution with Caenorhabditis Nematodes

The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model systems in biology since the 1970s, but only within the last two decades has this nematode also become a useful model for experimental evolution. Here, we outline the goals and major foci of experimental evolution w...

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Autores principales: Teotónio, Henrique, Estes, Suzanne, Phillips, Patrick C., Baer, Charles F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499180/
https://www.ncbi.nlm.nih.gov/pubmed/28592504
http://dx.doi.org/10.1534/genetics.115.186288
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author Teotónio, Henrique
Estes, Suzanne
Phillips, Patrick C.
Baer, Charles F.
author_facet Teotónio, Henrique
Estes, Suzanne
Phillips, Patrick C.
Baer, Charles F.
author_sort Teotónio, Henrique
collection PubMed
description The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model systems in biology since the 1970s, but only within the last two decades has this nematode also become a useful model for experimental evolution. Here, we outline the goals and major foci of experimental evolution with C. elegans and related species, such as C. briggsae and C. remanei, by discussing the principles of experimental design, and highlighting the strengths and limitations of Caenorhabditis as model systems. We then review three exemplars of Caenorhabditis experimental evolution studies, underlining representative evolution experiments that have addressed the: (1) maintenance of genetic variation; (2) role of natural selection during transitions from outcrossing to selfing, as well as the maintenance of mixed breeding modes during evolution; and (3) evolution of phenotypic plasticity and its role in adaptation to variable environments, including host–pathogen coevolution. We conclude by suggesting some future directions for which experimental evolution with Caenorhabditis would be particularly informative.
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spelling pubmed-54991802017-07-10 Experimental Evolution with Caenorhabditis Nematodes Teotónio, Henrique Estes, Suzanne Phillips, Patrick C. Baer, Charles F. Genetics WormBook The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model systems in biology since the 1970s, but only within the last two decades has this nematode also become a useful model for experimental evolution. Here, we outline the goals and major foci of experimental evolution with C. elegans and related species, such as C. briggsae and C. remanei, by discussing the principles of experimental design, and highlighting the strengths and limitations of Caenorhabditis as model systems. We then review three exemplars of Caenorhabditis experimental evolution studies, underlining representative evolution experiments that have addressed the: (1) maintenance of genetic variation; (2) role of natural selection during transitions from outcrossing to selfing, as well as the maintenance of mixed breeding modes during evolution; and (3) evolution of phenotypic plasticity and its role in adaptation to variable environments, including host–pathogen coevolution. We conclude by suggesting some future directions for which experimental evolution with Caenorhabditis would be particularly informative. Genetics Society of America 2017-06 2017 /pmc/articles/PMC5499180/ /pubmed/28592504 http://dx.doi.org/10.1534/genetics.115.186288 Text en Copyright © 2017 Teotónio et al. Available freely online through the author-supported open access option. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle WormBook
Teotónio, Henrique
Estes, Suzanne
Phillips, Patrick C.
Baer, Charles F.
Experimental Evolution with Caenorhabditis Nematodes
title Experimental Evolution with Caenorhabditis Nematodes
title_full Experimental Evolution with Caenorhabditis Nematodes
title_fullStr Experimental Evolution with Caenorhabditis Nematodes
title_full_unstemmed Experimental Evolution with Caenorhabditis Nematodes
title_short Experimental Evolution with Caenorhabditis Nematodes
title_sort experimental evolution with caenorhabditis nematodes
topic WormBook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499180/
https://www.ncbi.nlm.nih.gov/pubmed/28592504
http://dx.doi.org/10.1534/genetics.115.186288
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