Cargando…
A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
Of the many types of DNA damage, DNA double-strand breaks (DSBs) are probably the most deleterious. Mounting evidence points to an intricate relationship between DSBs and transcription. A cell system in which the impact on transcription can be investigated at precisely mapped genomic DSBs is essenti...
Autores principales: | Iannelli, Fabio, Galbiati, Alessandro, Capozzo, Ilaria, Nguyen, Quan, Magnuson, Brian, Michelini, Flavia, D’Alessandro, Giuseppina, Cabrini, Matteo, Roncador, Marco, Francia, Sofia, Crosetto, Nicola, Ljungman, Mats, Carninci, Piero, d’Adda di Fagagna, Fabrizio |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499205/ https://www.ncbi.nlm.nih.gov/pubmed/28561034 http://dx.doi.org/10.1038/ncomms15656 |
Ejemplares similares
-
DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
por: Cabrini, Matteo, et al.
Publicado: (2021) -
Damage-induced lncRNAs control the DNA damage response through
interaction with DDRNAs at individual double-strand breaks
por: Michelini, Flavia, et al.
Publicado: (2017) -
MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021) -
Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae
por: Manfrini, Nicola, et al.
Publicado: (2015) -
A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
por: Galbiati, Alessandro, et al.
Publicado: (2017)