Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug

In the title compound, [MeC(5)H(4)NCONHCH(2)C(6)H(5)]I or C(14)H(15)N(2)O(+)·I(−), a cation and an anion form an ionic pair linked by a strong N—H⋯I hydrogen bond. In the crystal, ionic pairs linked by weak C—H⋯I hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism sc...

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Autores principales: Drebushchak, T. N., Kryukov, Yu.A., Rogova, A. I., Boldyreva, E. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499270/
https://www.ncbi.nlm.nih.gov/pubmed/28775862
http://dx.doi.org/10.1107/S2056989017008155
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author Drebushchak, T. N.
Kryukov, Yu.A.
Rogova, A. I.
Boldyreva, E. V.
author_facet Drebushchak, T. N.
Kryukov, Yu.A.
Rogova, A. I.
Boldyreva, E. V.
author_sort Drebushchak, T. N.
collection PubMed
description In the title compound, [MeC(5)H(4)NCONHCH(2)C(6)H(5)]I or C(14)H(15)N(2)O(+)·I(−), a cation and an anion form an ionic pair linked by a strong N—H⋯I hydrogen bond. In the crystal, ionic pairs linked by weak C—H⋯I hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism screening varying crystallization solvents (water, acetone 90%–water, ethanol 90%–water, 2-propanol 90%–water, DMF, DMSO, methanol, aceto­nitrile) and conditions (solution temperature, heating and cooling protocols) did not reveal any other polymorphs than the one reported in this work.
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spelling pubmed-54992702017-08-03 Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug Drebushchak, T. N. Kryukov, Yu.A. Rogova, A. I. Boldyreva, E. V. Acta Crystallogr E Crystallogr Commun Research Communications In the title compound, [MeC(5)H(4)NCONHCH(2)C(6)H(5)]I or C(14)H(15)N(2)O(+)·I(−), a cation and an anion form an ionic pair linked by a strong N—H⋯I hydrogen bond. In the crystal, ionic pairs linked by weak C—H⋯I hydrogen bonds form infinite ribbons along the crystallographic a axis. Polymorphism screening varying crystallization solvents (water, acetone 90%–water, ethanol 90%–water, 2-propanol 90%–water, DMF, DMSO, methanol, aceto­nitrile) and conditions (solution temperature, heating and cooling protocols) did not reveal any other polymorphs than the one reported in this work. International Union of Crystallography 2017-06-07 /pmc/articles/PMC5499270/ /pubmed/28775862 http://dx.doi.org/10.1107/S2056989017008155 Text en © Drebushchak et al. 2017 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Drebushchak, T. N.
Kryukov, Yu.A.
Rogova, A. I.
Boldyreva, E. V.
Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title_full Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title_fullStr Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title_full_unstemmed Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title_short Crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
title_sort crystal structure of 4-benzyl­carbamoyl-1-methyl­pyridin-1-ium iodide: an efficient multimodal anti­viral drug
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499270/
https://www.ncbi.nlm.nih.gov/pubmed/28775862
http://dx.doi.org/10.1107/S2056989017008155
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