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Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan
Haptoglobin (Hp) is an acute phase protein that binds the free hemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has antioxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1, and Hp2-2. Hp polymorphisms have been related to sus...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università Cattolica del Sacro Cuore
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499500/ https://www.ncbi.nlm.nih.gov/pubmed/28698785 http://dx.doi.org/10.4084/MJHID.2017.042 |
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author | Yousif, Ashraf Siddig Elagib, Atif Abdelrahman |
author_facet | Yousif, Ashraf Siddig Elagib, Atif Abdelrahman |
author_sort | Yousif, Ashraf Siddig |
collection | PubMed |
description | Haptoglobin (Hp) is an acute phase protein that binds the free hemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has antioxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1, and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study, we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S. mansoni, 13 S. haematobium and 19 infected with both “co-infection”) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to Schistosoma parasites infection in central Sudan. |
format | Online Article Text |
id | pubmed-5499500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Università Cattolica del Sacro Cuore |
record_format | MEDLINE/PubMed |
spelling | pubmed-54995002017-07-11 Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan Yousif, Ashraf Siddig Elagib, Atif Abdelrahman Mediterr J Hematol Infect Dis Original Articles Haptoglobin (Hp) is an acute phase protein that binds the free hemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has antioxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1, and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study, we aimed to assess the possible association of Hp phenotypes polymorphism to Schistosoma parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 S. mansoni, 13 S. haematobium and 19 infected with both “co-infection”) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to Schistosoma parasites infection in central Sudan. Università Cattolica del Sacro Cuore 2017-07-01 /pmc/articles/PMC5499500/ /pubmed/28698785 http://dx.doi.org/10.4084/MJHID.2017.042 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Yousif, Ashraf Siddig Elagib, Atif Abdelrahman Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title | Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title_full | Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title_fullStr | Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title_full_unstemmed | Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title_short | Haptoglobin Phenotypes and Susceptibility to Schistosoma Parasites Infection in Central Sudan |
title_sort | haptoglobin phenotypes and susceptibility to schistosoma parasites infection in central sudan |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499500/ https://www.ncbi.nlm.nih.gov/pubmed/28698785 http://dx.doi.org/10.4084/MJHID.2017.042 |
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