Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation

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The catalytic activity of human cytidine deaminase APOBEC3B (A3B) has been correlated with kataegic mutational patterns within multiple cancer types. The molecular basis of how the N-terminal non-catalytic CD1 regulates the catalytic activity and consequently, biological function of A3B remains rela...

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Autores principales: Xiao, Xiao, Yang, Hanjing, Arutiunian, Vagan, Fang, Yao, Besse, Guillaume, Morimoto, Cherie, Zirkle, Brett, Chen, Xiaojiang S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499559/
https://www.ncbi.nlm.nih.gov/pubmed/28575276
http://dx.doi.org/10.1093/nar/gkx362
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