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SPA-LN: a scoring function of ligand–nucleic acid interactions via optimizing both specificity and affinity
Nucleic acids have been widely recognized as potential targets in drug discovery and aptamer selection. Quantifying the interactions between small molecules and nucleic acids is critical to discover lead compounds and design novel aptamers. Scoring function is normally employed to quantify the inter...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499587/ https://www.ncbi.nlm.nih.gov/pubmed/28431169 http://dx.doi.org/10.1093/nar/gkx255 |