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An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2–7

Mcm10 is an essential eukaryotic factor required for DNA replication. The replication fork helicase is composed of Cdc45, Mcm2–7 and GINS (CMG). DDK is an S-phase-specific kinase required for replication initiation, and the DNA primase-polymerase in eukaryotes is pol α. Mcm10 forms oligomers in vitr...

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Detalles Bibliográficos
Autores principales:	Perez-Arnaiz, Patricia, Bruck, Irina, Colbert, Max K., Kaplan, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499591/ https://www.ncbi.nlm.nih.gov/pubmed/28510759 http://dx.doi.org/10.1093/nar/gkx438

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