WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms

RNA-binding proteins (RBPs) are involved in mRNA splicing, maturation, transport, translation, storage and turnover. Here, we identified ACOT7 mRNA as a novel target of human WIG1. ACOT7 mRNA decay was triggered by the microRNA miR-9 in a WIG1-dependent manner via classic recruitment of Argonaute 2...

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Detalles Bibliográficos
Autores principales: Lee, Hyung Chul, Jung, Seung Hee, Hwang, Hyun Jung, Kang, Donghee, De, Supriyo, Dudekula, Dawood B., Martindale, Jennifer L., Park, Byungkyu, Park, Seung Kuk, Lee, Eun Kyung, Lee, Jeong-Hwa, Jeong, Sunjoo, Han, Kyungsook, Park, Heon Joo, Ko, Young-Gyu, Gorospe, Myriam, Lee, Jae-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499809/
https://www.ncbi.nlm.nih.gov/pubmed/28472401
http://dx.doi.org/10.1093/nar/gkx307

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