Cargando…

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide

The oxidized nucleotide, 8-oxo-7,8-dihydro-2΄-deoxyguanosine (8-oxoG), is one of the most abundant DNA lesions. 8-oxoG plays a major role in tumorigenesis and human disease. Biological consequences of 8-oxoG are mediated in part by its insertion into the genome, making it essential to understand how...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whitaker, Amy M., Smith, Mallory R., Schaich, Matthew A., Freudenthal, Bret D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499815/ https://www.ncbi.nlm.nih.gov/pubmed/28449123 http://dx.doi.org/10.1093/nar/gkx293

Ejemplares similares

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening
por: Kim, Taejin, et al.
Publicado: (2016)

Processing oxidatively damaged bases at DNA strand breaks by APE1
por: Whitaker, Amy M, et al.
Publicado: (2022)

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition
por: Smith, Mallory R, et al.
Publicado: (2019)

Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide
por: Singh, Isha, et al.
Publicado: (2018)

Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda
por: Burak, Matthew J., et al.
Publicado: (2015)

Mechanisms of nucleotide selection by telomerase
por: Schaich, Matthew A, et al.
Publicado: (2020)

Deaminated purine bypass by DNA polymerase η
por: Andreeva, Antonina
Publicado: (2021)

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase
por: Li, Zhuo, et al.
Publicado: (2022)

Uncovering the Polymerase-induced Cytotoxicty of an Oxidized Nucleotide
por: Freudenthal, Bret D., et al.
Publicado: (2014)

Structural basis for mammalian nucleotide sugar transport
por: Ahuja, Shivani, et al.
Publicado: (2019)

Structural basis of DNA polymerase θ mediated DNA end joining
por: Li, Chuxuan, et al.
Publicado: (2022)

Structural basis for the D-stereoselectivity of human DNA polymerase β
por: Vyas, Rajan, et al.
Publicado: (2017)

Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA
por: Wojtas, Magdalena N., et al.
Publicado: (2012)

Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase
por: Kirouac, Kevin N., et al.
Publicado: (2013)

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu
por: Moon, Andrea F., et al.
Publicado: (2017)

The proofreading exonuclease subunit ε of Escherichia coli DNA polymerase III is tethered to the polymerase subunit α via a flexible linker
por: Ozawa, Kiyoshi, et al.
Publicado: (2008)

RNA-dependent RNA polymerase of Japanese encephalitis virus binds the initiator nucleotide GTP to form a mechanistically important pre-initiation state
por: Surana, Parag, et al.
Publicado: (2014)

Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations
por: Azad, Robert N, et al.
Publicado: (2018)

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β
por: Koag, Myong-Chul, et al.
Publicado: (2014)

Structure of an ‘open’ clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport
por: Laponogov, Ivan, et al.
Publicado: (2013)

Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase
por: James, Tamara D., et al.
Publicado: (2016)

Thumb-domain dynamics modulate the functional repertoire of DNA-Polymerase IV (DinB)
por: Okeke, Damasus C, et al.
Publicado: (2023)

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase
por: Dehghani-Tafti, Saba, et al.
Publicado: (2019)

Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase
por: Ren, Zhong
Publicado: (2016)

Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors
por: Sanders, Cyril M., et al.
Publicado: (2007)

Solution structures of 2 : 1 and 1 : 1 DNA polymerase–DNA complexes probed by ultracentrifugation and small-angle X-ray scattering
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer
por: Nakamura, Teruya, et al.
Publicado: (2021)

A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping
por: Earl, Christopher, et al.
Publicado: (2018)

Mechanism for priming DNA synthesis by yeast DNA Polymerase α
por: Perera, Rajika L, et al.
Publicado: (2013)

Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)
por: Tang, Kuo-Hsiang, et al.
Publicado: (2008)

G-quadruplex formation at the 3′ end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase
por: Wang, Quan, et al.
Publicado: (2011)

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli
por: Sharma, Amit, et al.
Publicado: (2013)

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility
por: Powers, Kyle T, et al.
Publicado: (2018)

Structural dynamics and determinants of 2-aminoadenine specificity in DNA polymerase DpoZ of vibriophage ϕVC8
por: Czernecki, Dariusz, et al.
Publicado: (2021)

Classification of pseudo pairs between nucleotide bases and amino acids by analysis of nucleotide–protein complexes
por: Kondo, Jiro, et al.
Publicado: (2011)

Ctf18-RFC and DNA Pol ϵ form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication
por: Stokes, Katy, et al.
Publicado: (2020)

Solution structure of Domains IVa and V of the τ subunit of Escherichia coli DNA polymerase III and interaction with the α subunit
por: Su, Xun-Cheng, et al.
Publicado: (2007)

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ
por: Jha, Vikash, et al.
Publicado: (2016)

The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair
por: González-Corrochano, Rocío, et al.
Publicado: (2020)

Modular architecture of nucleotide-binding pockets
por: Gherardini, Pier Federico, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5279jso7bvamuvjtabc97pdmh4