Cargando…

PRL-3 promotes telomere deprotection and chromosomal instability

Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic integrity remains unknown. We report here that shelterin component RAP1 mediates association between PRL-3 and TRF2. In addition, TRF2 and RAP1 assist recruitment of PRL-3 to telomeric DNA. Silencing of PRL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lian, Shenyi, Meng, Lin, Yang, Yongyong, Ma, Ting, Xing, Xiaofang, Feng, Qin, Song, Qian, Liu, Caiyun, Tian, Zhihua, Qu, Like, Shou, Chengchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499835/ https://www.ncbi.nlm.nih.gov/pubmed/28482095 http://dx.doi.org/10.1093/nar/gkx392

Ejemplares similares

PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer
por: Lian, Shenyi, et al.
Publicado: (2016)

Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion
por: Yang, Yongyong, et al.
Publicado: (2017)

Telomere-associated proteins add deoxynucleotides to terminal proteins during replication of the telomeres of linear chromosomes and plasmids in Streptomyces
por: Yang, Chien-Chin, et al.
Publicado: (2015)

Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells
por: Pennarun, Gaëlle, et al.
Publicado: (2021)

Human telomeres that contain (CTAGGG)(n) repeats show replication dependent instability in somatic cells and the male germline
por: Mendez-Bermudez, Aaron, et al.
Publicado: (2009)

Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells
por: Jia, Pingping, et al.
Publicado: (2017)

The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm
por: Ayuda-Durán, Pilar, et al.
Publicado: (2014)

Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection
por: Klebanov-Akopyan, Olga, et al.
Publicado: (2018)

Telomere associated primase Tap repairs truncated telomeres of Streptomyces
por: Yang, Chien-Chin, et al.
Publicado: (2017)

Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells
por: Almeida, Hugo, et al.
Publicado: (2013)

DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP
por: Mimmler, Maximilian, et al.
Publicado: (2016)

Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome
por: Huang, Yan, et al.
Publicado: (2014)

Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1
por: Yang, Yongyong, et al.
Publicado: (2018)

Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeast
por: Lu, Chia-Yin, et al.
Publicado: (2010)

Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
por: Maicher, André, et al.
Publicado: (2012)

SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates
por: Sarkar, Jaya, et al.
Publicado: (2015)

Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres
por: Stivison, Elizabeth A, et al.
Publicado: (2020)

Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction
por: Oh, Sehyun, et al.
Publicado: (2013)

Long-read sequencing and de novo genome assemblies reveal complex chromosome end structures caused by telomere dysfunction at the single nucleotide level
por: Kim, Eunkyeong, et al.
Publicado: (2021)

A new assay capturing chromosome fusions shows a protection trade-off at telomeres and NHEJ vulnerability to low-density ionizing radiation
por: Pobiega, Sabrina, et al.
Publicado: (2021)

Nuclear envelope attachment of telomeres limits TERRA and telomeric rearrangements in quiescent fission yeast cells
por: Maestroni, Laetitia, et al.
Publicado: (2020)

Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast
por: Greenwood, Jessica, et al.
Publicado: (2012)

Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups
por: Rubinstein, Linda, et al.
Publicado: (2014)

Shelterin reduces the accessibility of telomeric overhangs
por: Shiekh, Sajad, et al.
Publicado: (2022)

Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
por: Nora, Gerald J., et al.
Publicado: (2010)

Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability
por: Colosio, Arianna, et al.
Publicado: (2016)

The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells
por: Fernandes, Rita Valador, et al.
Publicado: (2023)

A critical role of telomere chromatin compaction in ALT tumor cell growth
por: Shi, Guang, et al.
Publicado: (2020)

ATR contributes to telomere maintenance in human cells
por: Pennarun, Gaëlle, et al.
Publicado: (2010)

Length-dependent processing of telomeres in the absence of telomerase
por: Fallet, Emilie, et al.
Publicado: (2014)

Human RECQL1 participates in telomere maintenance
por: Popuri, Venkateswarlu, et al.
Publicado: (2014)

POLIE suppresses telomerase-mediated telomere G-strand extension and helps ensure proper telomere C-strand synthesis in trypanosomes
por: Rabbani, M A G, et al.
Publicado: (2022)

Polymerases ε and ∂ repair dysfunctional telomeres facilitated by salt
por: Ivanova, Iglika G., et al.
Publicado: (2016)

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling
por: Peng, Lirong, et al.
Publicado: (2009)

Heavy metal ions exchange driven protein phosphorylation cascade functions in genomic instability in spermatocytes and male infertility
por: Li, Ren-Yan, et al.
Publicado: (2023)

Investigating the role of the Est3 protein in yeast telomere replication
por: Lee, Jaesung, et al.
Publicado: (2010)

Origin-dependent initiation of DNA replication within telomeric sequences
por: Kurth, Isabel, et al.
Publicado: (2010)

A role for monoubiquitinated FANCD2 at telomeres in ALT cells
por: Fan, Qiang, et al.
Publicado: (2009)

Translesion-synthesis DNA polymerases participate in replication of the telomeres in Streptomyces
por: Tsai, Hsiu-Hui, et al.
Publicado: (2012)

Interaction of human telomeric DNA with N-methyl mesoporphyrin IX
por: Nicoludis, John M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5i6kblvil1snlgdcqgd1l6lgfu