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Brain metabolite values in children with breath-holding spells
Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic res...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499924/ https://www.ncbi.nlm.nih.gov/pubmed/28721046 http://dx.doi.org/10.2147/NDT.S135842 |
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author | Calik, Mustafa Sen Dokumaci, Dilek Sarikaya, Suna Demir, Mahmut Isik, Ilhan Kazanasmaz, Halil Kaya, Cemil Kandemir, Hasan |
author_facet | Calik, Mustafa Sen Dokumaci, Dilek Sarikaya, Suna Demir, Mahmut Isik, Ilhan Kazanasmaz, Halil Kaya, Cemil Kandemir, Hasan |
author_sort | Calik, Mustafa |
collection | PubMed |
description | Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. |
format | Online Article Text |
id | pubmed-5499924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54999242017-07-18 Brain metabolite values in children with breath-holding spells Calik, Mustafa Sen Dokumaci, Dilek Sarikaya, Suna Demir, Mahmut Isik, Ilhan Kazanasmaz, Halil Kaya, Cemil Kandemir, Hasan Neuropsychiatr Dis Treat Original Research Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. Dove Medical Press 2017-06-26 /pmc/articles/PMC5499924/ /pubmed/28721046 http://dx.doi.org/10.2147/NDT.S135842 Text en © 2017 Calik et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Calik, Mustafa Sen Dokumaci, Dilek Sarikaya, Suna Demir, Mahmut Isik, Ilhan Kazanasmaz, Halil Kaya, Cemil Kandemir, Hasan Brain metabolite values in children with breath-holding spells |
title | Brain metabolite values in children with breath-holding spells |
title_full | Brain metabolite values in children with breath-holding spells |
title_fullStr | Brain metabolite values in children with breath-holding spells |
title_full_unstemmed | Brain metabolite values in children with breath-holding spells |
title_short | Brain metabolite values in children with breath-holding spells |
title_sort | brain metabolite values in children with breath-holding spells |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499924/ https://www.ncbi.nlm.nih.gov/pubmed/28721046 http://dx.doi.org/10.2147/NDT.S135842 |
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