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Brain metabolite values in children with breath-holding spells

Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic res...

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Autores principales: Calik, Mustafa, Sen Dokumaci, Dilek, Sarikaya, Suna, Demir, Mahmut, Isik, Ilhan, Kazanasmaz, Halil, Kaya, Cemil, Kandemir, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499924/
https://www.ncbi.nlm.nih.gov/pubmed/28721046
http://dx.doi.org/10.2147/NDT.S135842
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author Calik, Mustafa
Sen Dokumaci, Dilek
Sarikaya, Suna
Demir, Mahmut
Isik, Ilhan
Kazanasmaz, Halil
Kaya, Cemil
Kandemir, Hasan
author_facet Calik, Mustafa
Sen Dokumaci, Dilek
Sarikaya, Suna
Demir, Mahmut
Isik, Ilhan
Kazanasmaz, Halil
Kaya, Cemil
Kandemir, Hasan
author_sort Calik, Mustafa
collection PubMed
description Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells.
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spelling pubmed-54999242017-07-18 Brain metabolite values in children with breath-holding spells Calik, Mustafa Sen Dokumaci, Dilek Sarikaya, Suna Demir, Mahmut Isik, Ilhan Kazanasmaz, Halil Kaya, Cemil Kandemir, Hasan Neuropsychiatr Dis Treat Original Research Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. Dove Medical Press 2017-06-26 /pmc/articles/PMC5499924/ /pubmed/28721046 http://dx.doi.org/10.2147/NDT.S135842 Text en © 2017 Calik et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Calik, Mustafa
Sen Dokumaci, Dilek
Sarikaya, Suna
Demir, Mahmut
Isik, Ilhan
Kazanasmaz, Halil
Kaya, Cemil
Kandemir, Hasan
Brain metabolite values in children with breath-holding spells
title Brain metabolite values in children with breath-holding spells
title_full Brain metabolite values in children with breath-holding spells
title_fullStr Brain metabolite values in children with breath-holding spells
title_full_unstemmed Brain metabolite values in children with breath-holding spells
title_short Brain metabolite values in children with breath-holding spells
title_sort brain metabolite values in children with breath-holding spells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499924/
https://www.ncbi.nlm.nih.gov/pubmed/28721046
http://dx.doi.org/10.2147/NDT.S135842
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