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Patients harboring ALK rearrangement adenocarcinoma after acquired resistance to crizotinib and transformation to small-cell lung cancer: a case report

Anaplastic lymphoma kinase (ALK) rearrangement responds to ALK tyrosine kinase inhibitors (TKIs) in lung cancer. Many cases ultimately acquire resistance to crizotinib. Resistance, including ALK-dominant or ALK non-dominant, mechanisms have been described. Transformation to small-cell lung cancer is...

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Detalles Bibliográficos
Autores principales:	Zhu, You-cai, Liao, Xing-hui, Wang, Wen-xian, Xu, Chun-wei, Zhuang, Wu, Zhong, Li-hua, Du, Kai-qi, Chen, Yan-ping, Chen, Gang, Fang, Mei-yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499929/ https://www.ncbi.nlm.nih.gov/pubmed/28721068 http://dx.doi.org/10.2147/OTT.S139718

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