The role of microglia in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. I...

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Detalles Bibliográficos
Autores principales: Luo, Chun, Jian, Chongdong, Liao, Yuhan, Huang, Qi, Wu, Yuejuan, Liu, Xixia, Zou, Donghua, Wu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499932/
https://www.ncbi.nlm.nih.gov/pubmed/28721047
http://dx.doi.org/10.2147/NDT.S140634
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author Luo, Chun
Jian, Chongdong
Liao, Yuhan
Huang, Qi
Wu, Yuejuan
Liu, Xixia
Zou, Donghua
Wu, Yuan
author_facet Luo, Chun
Jian, Chongdong
Liao, Yuhan
Huang, Qi
Wu, Yuejuan
Liu, Xixia
Zou, Donghua
Wu, Yuan
author_sort Luo, Chun
collection PubMed
description Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings.
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spelling pubmed-54999322017-07-18 The role of microglia in multiple sclerosis Luo, Chun Jian, Chongdong Liao, Yuhan Huang, Qi Wu, Yuejuan Liu, Xixia Zou, Donghua Wu, Yuan Neuropsychiatr Dis Treat Review Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Microglia are the resident innate immune cells in the CNS; they play an important role in the processes of demyelination and remyelination in MS. Microglia can function as antigen-presenting cells and phagocytes. In the past, microglia were considered to be the same cell type as macrophages, and researchers have different opinions about the role of microglia in MS. This review focuses on the original classification of microglia and their role in the pathogenesis of MS. Moreover, we present a hypothetical model for the role of microglia in the pathogenesis of MS based on recent findings. Dove Medical Press 2017-06-26 /pmc/articles/PMC5499932/ /pubmed/28721047 http://dx.doi.org/10.2147/NDT.S140634 Text en © 2017 Luo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Luo, Chun
Jian, Chongdong
Liao, Yuhan
Huang, Qi
Wu, Yuejuan
Liu, Xixia
Zou, Donghua
Wu, Yuan
The role of microglia in multiple sclerosis
title The role of microglia in multiple sclerosis
title_full The role of microglia in multiple sclerosis
title_fullStr The role of microglia in multiple sclerosis
title_full_unstemmed The role of microglia in multiple sclerosis
title_short The role of microglia in multiple sclerosis
title_sort role of microglia in multiple sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499932/
https://www.ncbi.nlm.nih.gov/pubmed/28721047
http://dx.doi.org/10.2147/NDT.S140634
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