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The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature
Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499939/ https://www.ncbi.nlm.nih.gov/pubmed/28721049 http://dx.doi.org/10.2147/NDT.S136065 |
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author | Nicholson, William C Kempf, Mirjam-Colette Moneyham, Linda Vance, David E |
author_facet | Nicholson, William C Kempf, Mirjam-Colette Moneyham, Linda Vance, David E |
author_sort | Nicholson, William C |
collection | PubMed |
description | Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike. Interestingly, the parasympathetic system-associated vagus nerve (VN) has primary homeostatic properties that restore CNS function following a stress or inflammatory response. Unfortunately, about 30% of adults with HIV are resistant to standard psychotherapeutic and psychopharmacological treatments for depression, thus suggesting the need for alternative treatment approaches. VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. Historically, VNS has been delivered using a surgically implanted device; however, transcutanous VNS (tVNS) with nonsurgical auricular technology is now available. Although it currently lacks Food and Drug Administration approval in the US, evidence suggests several advantages of tVNS, including a reduced side-effect profile when compared to standard treatments and comparable results to implantable VNS in treating depression. Therefore, tVNS could offer an alternative for managing depression in HIV via regulating CNS function; moreover, tVNS may be useful for treatment of other symptoms common in HIV. From this, implications for nursing research and practice are provided. |
format | Online Article Text |
id | pubmed-5499939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-54999392017-07-18 The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature Nicholson, William C Kempf, Mirjam-Colette Moneyham, Linda Vance, David E Neuropsychiatr Dis Treat Review Depression is the most common comorbidity and neuropsychiatric complication in HIV. Estimates suggest that the prevalence rate for depression among HIV-infected individuals is three times that of the general population. The association between HIV and clinical depression is complex; however, chronic activation of inflammatory mechanisms, which disrupt central nervous system (CNS) function, may contribute to this association. Disruptions in CNS function can result in cognitive disorders, social withdrawal, fatigue, apathy, psychomotor impairment, and sleep disturbances, which are common manifestations in depression and HIV alike. Interestingly, the parasympathetic system-associated vagus nerve (VN) has primary homeostatic properties that restore CNS function following a stress or inflammatory response. Unfortunately, about 30% of adults with HIV are resistant to standard psychotherapeutic and psychopharmacological treatments for depression, thus suggesting the need for alternative treatment approaches. VN stimulation (VNS) and its benefits as a treatment for depression have been well documented, but remain unexplored in the HIV population. Historically, VNS has been delivered using a surgically implanted device; however, transcutanous VNS (tVNS) with nonsurgical auricular technology is now available. Although it currently lacks Food and Drug Administration approval in the US, evidence suggests several advantages of tVNS, including a reduced side-effect profile when compared to standard treatments and comparable results to implantable VNS in treating depression. Therefore, tVNS could offer an alternative for managing depression in HIV via regulating CNS function; moreover, tVNS may be useful for treatment of other symptoms common in HIV. From this, implications for nursing research and practice are provided. Dove Medical Press 2017-06-28 /pmc/articles/PMC5499939/ /pubmed/28721049 http://dx.doi.org/10.2147/NDT.S136065 Text en © 2017 Nicholson et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Nicholson, William C Kempf, Mirjam-Colette Moneyham, Linda Vance, David E The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title | The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title_full | The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title_fullStr | The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title_full_unstemmed | The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title_short | The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature |
title_sort | potential role of vagus-nerve stimulation in the treatment of hiv-associated depression: a review of literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499939/ https://www.ncbi.nlm.nih.gov/pubmed/28721049 http://dx.doi.org/10.2147/NDT.S136065 |
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